Literature DB >> 17846572

Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase.

Nisachon Khunnawutmanotham1, Nitirat Chimnoi, Patchareenart Saparpakorn, Pornpan Pungpo, Suda Louisirirotchanakul, Supa Hannongbua, Supanna Techasakul.   

Abstract

Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8-arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17846572      PMCID： PMC6149348          DOI： 10.3390/12020218

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  10 in total

1.  International perspectives on antiretroviral resistance. Introduction.

Authors:  P Volberding; J Lange
Journal:  J Acquir Immune Defic Syndr       Date:  2001-03-01       Impact factor: 3.731

Review 2.  International perspectives on antiretroviral resistance. Nucleoside reverse transcriptase inhibitor resistance.

Authors:  C Loveday
Journal:  J Acquir Immune Defic Syndr       Date:  2001-03-01       Impact factor: 3.731

Review 3.  International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance.

Authors:  S G Deeks
Journal:  J Acquir Immune Defic Syndr       Date:  2001-03-01       Impact factor: 3.731

Review 4.  HIV-1 cell entry and advances in viral entry inhibitor therapy.

Authors:  Louise A Cooley; Sharon R Lewin
Journal:  J Clin Virol       Date:  2003-02       Impact factor: 3.168

5.  Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones.

Authors:  K D Hargrave; J R Proudfoot; K G Grozinger; E Cullen; S R Kapadia; U R Patel; V U Fuchs; S C Mauldin; J Vitous; M L Behnke
Journal:  J Med Chem       Date:  1991-07       Impact factor: 7.446

6.  Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.

Authors:  Jeff A O'Meara; Christiane Yoakim; Pierre R Bonneau; Michael Bös; Michael G Cordingley; Robert Déziel; Louise Doyon; Jianmin Duan; Michel Garneau; Ingrid Guse; Serge Landry; Eric Malenfant; Julie Naud; William W Ogilvie; Bounkham Thavonekham; Bruno Simoneau
Journal:  J Med Chem       Date:  2005-08-25       Impact factor: 7.446

7.  Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 8. 8-Aryloxymethyl- and 8-arylthiomethyldipyridodiazepinones.

Authors:  C L Cywin; J M Klunder; M Hoermann; J R Brickwood; E David; P M Grob; R Schwartz; D Pauletti; K J Barringer; C K Shih; C L Sorge; D A Erickson; D P Joseph; S E Hattox
Journal:  J Med Chem       Date:  1998-07-30       Impact factor: 7.446

8.  Hologram quantitative structure-activity relationships investigations of non-nucleoside reverse transcriptase inhibitors.

Authors:  Pornpan Pungpo; Supa Hannongbua; Peter Wolschann
Journal:  Curr Med Chem       Date:  2003-09       Impact factor: 4.530

9.  Public health implications of antiretroviral therapy and HIV drug resistance.

Authors:  M A Wainberg; G Friedland
Journal:  JAMA       Date:  1998-06-24       Impact factor: 56.272

Review 10.  Antiviral drugs in current clinical use.

Authors:  Erik De Clercq
Journal:  J Clin Virol       Date:  2004-06       Impact factor: 3.168
  10 in total
  1 in total

1.  Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity.

Authors:  Nisachon Khunnawutmanotham; Nitirat Chimnoi; Arunee Thitithanyanont; Patchreenart Saparpakorn; Kiattawee Choowongkomon; Pornpan Pungpo; Supa Hannongbua; Supanna Techasakul
Journal:  Beilstein J Org Chem       Date:  2009-07-22       Impact factor: 2.883
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.