BACKGROUND AND PURPOSE: Nonimaging transcranial Doppler sonography (TCD) and imaging TCD (TCDI) are used for determination of the risk of stroke in children with sickle cell disease (SCD). The purpose was to compare angle-corrected, uncorrected TCDI, and TCD blood flow velocities in children with SCD. MATERIALS AND METHODS: A total of 37 children (mean age, 7.8 +/- 3.0 years) without intracranial arterial narrowing determined with MR angiography, were studied with use of TCD and TCDI at the same session. Depth of insonation and TCDI mean velocities with and without correction for the angle of insonation in the terminal internal carotid artery (ICA) and middle (MCA), anterior (ACA), and posterior (PCA) cerebral arteries were compared with TCD velocities with use of a paired t test. RESULTS: Two arteries were not found on TCDI compared with 15 not found on TCD. Average angle of insonation in the MCA, ACA, ICA, and PCA was 31 degrees , 44 degrees , 25 degrees , and 29 degrees , respectively. TCDI and TCD mean depth of insonation for all arteries did not differ significantly; however, individual differences varied substantially. TCDI velocities were significantly lower than TCD velocities, respectively, for the right and left sides (mean +/- SD): MCA, 106 +/- 22 cm/s and 111 +/- 33 cm/s versus 130 +/- 19 cm/s and 134 +/- 26 cm/s; ICA, 90 +/- 14 cm/s and 98 +/- 27 cm/s versus 117 +/- 18 cm/s and 119 +/- 23 cm/s; ACA, 74 +/- 24 cm/s and 88 +/- 25 cm/s versus 105 +/- 23 cm/s and 105 +/- 31 cm/s; and PCA, 84 +/- 27 cm/s and 82 +/- 21 cm/s versus 95 +/- 23 cm/s and 94 +/- 20 cm/s. TCD and angle-corrected TCDI velocities were not statistically different except for higher angle-corrected TCDI values in the left ACA and right PCA. CONCLUSION: TCD velocities are significantly higher than TCDI velocities but are not different from the angle-corrected TCDI velocities. TCDI identifies the major intracranial arteries more effectively than TCD.
BACKGROUND AND PURPOSE: Nonimaging transcranial Doppler sonography (TCD) and imaging TCD (TCDI) are used for determination of the risk of stroke in children with sickle cell disease (SCD). The purpose was to compare angle-corrected, uncorrected TCDI, and TCD blood flow velocities in children with SCD. MATERIALS AND METHODS: A total of 37 children (mean age, 7.8 +/- 3.0 years) without intracranial arterial narrowing determined with MR angiography, were studied with use of TCD and TCDI at the same session. Depth of insonation and TCDI mean velocities with and without correction for the angle of insonation in the terminal internal carotid artery (ICA) and middle (MCA), anterior (ACA), and posterior (PCA) cerebral arteries were compared with TCD velocities with use of a paired t test. RESULTS: Two arteries were not found on TCDI compared with 15 not found on TCD. Average angle of insonation in the MCA, ACA, ICA, and PCA was 31 degrees , 44 degrees , 25 degrees , and 29 degrees , respectively. TCDI and TCD mean depth of insonation for all arteries did not differ significantly; however, individual differences varied substantially. TCDI velocities were significantly lower than TCD velocities, respectively, for the right and left sides (mean +/- SD): MCA, 106 +/- 22 cm/s and 111 +/- 33 cm/s versus 130 +/- 19 cm/s and 134 +/- 26 cm/s; ICA, 90 +/- 14 cm/s and 98 +/- 27 cm/s versus 117 +/- 18 cm/s and 119 +/- 23 cm/s; ACA, 74 +/- 24 cm/s and 88 +/- 25 cm/s versus 105 +/- 23 cm/s and 105 +/- 31 cm/s; and PCA, 84 +/- 27 cm/s and 82 +/- 21 cm/s versus 95 +/- 23 cm/s and 94 +/- 20 cm/s. TCD and angle-corrected TCDI velocities were not statistically different except for higher angle-corrected TCDI values in the left ACA and right PCA. CONCLUSION:TCD velocities are significantly higher than TCDI velocities but are not different from the angle-corrected TCDI velocities. TCDI identifies the major intracranial arteries more effectively than TCD.
Authors: Robert J Adams; Donald J Brambilla; Suzanne Granger; Dianne Gallagher; Elliott Vichinsky; Miguel R Abboud; Charles H Pegelow; Gerald Woods; Elizabeth M Rohde; Fenwick T Nichols; Anne Jones; Judith P Luden; Latonya Bowman; Susan Hagner; Knashawn H Morales; E Steve Roach Journal: Blood Date: 2004-01-29 Impact factor: 22.113
Authors: Mikolaj A Pawlak; Jaroslaw Krejza; Wojciech Rudzinski; Janet L Kwiatkowski; Rebecca Ichord; Abbas F Jawad; Maciej Tomaszewski; Elias R Melhem Journal: Radiology Date: 2009-05 Impact factor: 11.105
Authors: Jaroslaw Krejza; Rong Chen; Grzegorz Romanowicz; Janet L Kwiatkowski; Rebecca Ichord; Michal Arkuszewski; Robert Zimmerman; Kwaku Ohene-Frempong; Lisa Desiderio; Elias R Melhem Journal: Stroke Date: 2010-11-18 Impact factor: 7.914
Authors: Julie Kanter; Shannon Phillips; Alyssa M Schlenz; Martina Mueller; Mary Dooley; Logan Sirline; Robert Nickel; Robert Clark Brown; Lee Hilliard; Cathy L Melvin; Robert J Adams Journal: J Pediatr Hematol Oncol Date: 2021-11-01 Impact factor: 1.289
Authors: Clarisse Lopes de Castro Lobo; Rodolfo Delfini Cançado; Ana Claudia Celestino Bezerra Leite; Ana Claudia Mendonça Dos Anjos; Ana Cristina Silva Pinto; Andre Palma da Cunha Matta; Célia Maria Silva; Gisele Sampaio Silva; João Ricardo Friedrisch; Josefina Aparecida Pellegrini Braga; Marcos Christiano Lange; Maria Stella Figueiredo; Marília Álvares Rugani; Orlando Veloso; Patrícia Gomes Moura; Paulo Ivo Cortez; Robert Adams; Sandra Fátima Menosi Gualandro; Shirley Lopes de Castilho; Ursula Thomé; Viviane Flumignan Zetola Journal: Rev Bras Hematol Hemoter Date: 2011