| Literature DB >> 17845852 |
Ariel Ruiz i Altaba1, Christophe Mas, Barbara Stecca.
Abstract
The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.Entities:
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Year: 2007 PMID： 17845852 PMCID： PMC2601665 DOI： 10.1016/j.tcb.2007.06.007
Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808