Literature DB >> 1784504

Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine.

Franco de Conno1, Augusto Caraceni, Cinzia Martini, Elio Spoldi, Monica Salvetti, Vittorio Ventafridda.   

Abstract

We report the case of a patient who developed myoclonus and hyperalgesia following administration of high-dose subarachnoid morphine. This complication occurred with 40-80 mg/day continuous infusion. The pathophysiology of these side effects is discussed.

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Year:  1991        PMID： 1784504     DOI： 10.1016/0304-3959(91)90225-M

Source DB:  PubMed          Journal:  Pain        ISSN： 0304-3959            Impact factor:   6.961


  22 in total

1.  Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance.

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2.  Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process.

Authors:  E Célèrier; J P Laulin; J B Corcuff; M Le Moal; G Simonnet
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3.  Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance.

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Journal:  J Neurosci       Date:  2000-09-15       Impact factor: 6.167

Review 4.  Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations.

Authors:  Caroline A Arout; Ellen Edens; Ismene L Petrakis; Mehmet Sofuoglu
Journal:  CNS Drugs       Date:  2015-06       Impact factor: 5.749

5.  Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na+ channel function of dorsal root ganglia.

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6.  Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor.

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7.  Differential tolerance to morphine antinociception in assays of pain-stimulated vs. pain-depressed behavior in rats.

Authors:  Ahmad A Altarifi; S Stevens Negus
Journal:  Eur J Pharmacol       Date:  2014-12-18       Impact factor: 4.432

8.  Altered quantitative sensory testing outcome in subjects with opioid therapy.

Authors:  Lucy Chen; Charlene Malarick; Lindsey Seefeld; Shuxing Wang; Mary Houghton; Jianren Mao
Journal:  Pain       Date:  2009-02-23       Impact factor: 6.961

Review 9.  Drug-induced myoclonus: frequency, mechanisms and management.

Authors:  Félix Javier Jiménez-Jiménez; Inmaculada Puertas; María de Toledo-Heras
Journal:  CNS Drugs       Date:  2004       Impact factor: 5.749

10.  Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice.

Authors:  Carolina Muscoli; Salvatore Cuzzocrea; Michael M Ndengele; Vincenzo Mollace; Frank Porreca; Francesca Fabrizi; Emanuela Esposito; Emanuela Masini; George M Matuschak; Daniela Salvemini
Journal:  J Clin Invest       Date:  2007-11       Impact factor: 14.808
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