Literature DB >> 1784332

Fluoroacetate and fluorocitrate: mechanism of action.

D D Clarke1.   

Abstract

The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glial-neuronal relationships is considered.

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Year:  1991        PMID： 1784332     DOI： 10.1007/bf00965850

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  19 in total

1.  FLUOROACETATE AND THE METABOLISM OF AMMONIA IN BRAIN.

Authors:  S LAHIRI; J H QUASTEL
Journal:  Biochem J       Date:  1963-10       Impact factor: 3.857

2.  Triethyl alpha-fluoroaconitate.

Authors:  E D BERGMANN; I SHAHAK
Journal:  Nature       Date:  1960-02-20       Impact factor: 49.962

3.  Fluorocitrate inhibition of aconitase. Reversibility of the inactivation.

Authors:  J J Villafranca; E Platus
Journal:  Biochem Biophys Res Commun       Date:  1973-12-19       Impact factor: 3.575

4.  The effect of injections of fluorocitrate into the brains of rats.

Authors:  P L Morselli; S Garattini; F Marcucci; E Mussini; W Rewersky; L Valzelli; R A Peters
Journal:  Biochem Pharmacol       Date:  1968-02       Impact factor: 5.858

5.  An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: the use of fluorocitrate.

Authors:  R E Paulsen; A Contestabile; L Villani; F Fonnum
Journal:  J Neurochem       Date:  1987-05       Impact factor: 5.372

Review 6.  Fluorinated substrate analogs: routes of metabolism and selective toxicity.

Authors:  C Walsh
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1983

7.  Absolute configuration of the isomer of fluorocitrate that inhibits aconitase.

Authors:  W C Stallings; C T Monti; J F Belvedere; R K Preston; J P Glusker
Journal:  Arch Biochem Biophys       Date:  1980-08       Impact factor: 4.013

8.  Enzymatic defluorination and metabolism of fluoroacetate, fluoroacetamide, fluoroethanol, and (-)-erythro-fluorocitrate in rats and mice examined by 19F and 13C NMR.

Authors:  B Tecle; J E Casida
Journal:  Chem Res Toxicol       Date:  1989 Nov-Dec       Impact factor: 3.739

9.  Stereochemical studies on the hydration of monofluorofumarate and 2,3-difluorofumarate by fumarase.

Authors:  M A Marletta; Y F Cheung; C Walsh
Journal:  Biochemistry       Date:  1982-05-25       Impact factor: 3.162

10.  Enzymatic formation of glutathione-citryl thioester by a mitochondrial system and its inhibition by (-)erythrofluorocitrate.

Authors:  E Kun; E Kirsten; M L Sharma
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205
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  41 in total

1.  Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.

Authors:  Manickavasagom Alkondon; Edna F R Pereira; Howard M Eisenberg; Yasushi Kajii; Robert Schwarcz; Edson X Albuquerque
Journal:  J Pharmacol Exp Ther       Date:  2011-01-26       Impact factor: 4.030

2.  Evidence for involvement of glial cell activity in the control of extracellular D-serine contents in the rat brain.

Authors:  S Kanematsu; S Ishii; A Umino; T Fujihira; A Kashiwa; N Yamamoto; A Kurumaji; T Nishikawa
Journal:  J Neural Transm (Vienna)       Date:  2006-06-01       Impact factor: 3.575

3.  Hindbrain cytoglucopenia-induced increases in systemic blood glucose levels by 2-deoxyglucose depend on intact astrocytes and adenosine release.

Authors:  Richard C Rogers; Sue Ritter; Gerlinda E Hermann
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2016-04-13       Impact factor: 3.619

Review 4.  Neuronal P2X7 Receptors Revisited: Do They Really Exist?

Authors:  Peter Illes; Tahir Muhammad Khan; Patrizia Rubini
Journal:  J Neurosci       Date:  2017-07-26       Impact factor: 6.167

5.  Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with ¹⁸F-FAHA.

Authors:  Hsin-Hsien Yeh; Mei Tian; Rainer Hinz; Daniel Young; Alexander Shavrin; Uday Mukhapadhyay; Leo G Flores; Julius Balatoni; Suren Soghomonyan; Hwan J Jeong; Ashutosh Pal; Rajesh Uthamanthil; James N Jackson; Ryuichi Nishii; Hiroshi Mizuma; Hirotaka Onoe; Shinya Kagawa; Tatsuya Higashi; Nobuyoshi Fukumitsu; Mian Alauddin; William Tong; Karl Herholz; Juri G Gelovani
Journal:  Neuroimage       Date:  2012-09-17       Impact factor: 6.556

6.  Catalytic control of enzymatic fluorine specificity.

Authors:  Amy M Weeks; Michelle C Y Chang
Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-12       Impact factor: 11.205

7.  PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.

Authors:  Katie M Vance; Richard C Rogers; Gerlinda E Hermann
Journal:  J Neurosci       Date:  2015-01-14       Impact factor: 6.167

8.  Amino acid-induced [Ca2+]i oscillations in single mouse pancreatic islets of Langerhans.

Authors:  F Martin; B Soria
Journal:  J Physiol       Date:  1995-07-15       Impact factor: 5.182

9.  Functional P2X7 receptors at cultured hippocampal astrocytes but not neurons.

Authors:  Patrizia Rubini; Gregor Pagel; Soghra Mehri; Peter Marquardt; Thomas Riedel; Peter Illes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-06-25       Impact factor: 3.000

10.  Inhibition of mitochondrial function in astrocytes: implications for neuroprotection.

Authors:  Ludmila A Voloboueva; Sang Won Suh; Raymond A Swanson; Rona G Giffard
Journal:  J Neurochem       Date:  2007-08       Impact factor: 5.372
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