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Literature DB >> 1784330

Some metabolic relationships between biopterin and folate: implications for the "methyl trap hypothesis".

Abstract

Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide an escape from the "methyl trap."

Entities: Chemical

Mesh：

Substances：

Year: 1991 PMID： 1784330 DOI： 10.1007/bf00965847

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

31 in total

1. LEVELS OF DIHYDROFOLATE REDUCTASE AND THE FORMATE-ACTIVATING ENZYME ACTIVITIES IN GUINEA PIG TISSUES BEFORE AND AFTER AMETHOPTERIN ADMINISTRATION.

Authors: J R BERTINO; B SIMMONS; D M DONOHUE
Journal: Biochem Pharmacol Date: 1964-02 Impact factor: 5.858

2. THE STRUCTURE OF THE PHENYLALANINE-HYDROXYLATION COFACTOR.

Authors: S KAUFMAN
Journal: Proc Natl Acad Sci U S A Date: 1963-12 Impact factor: 11.205

3. The role of dihydrofolic reductase in the metabolism of one-carbon units.

Authors: F M HUENNEKENS
Journal: Biochemistry Date: 1963 Jan-Feb Impact factor: 3.162

4. Dihydropteridine reductase may function in tetrahydrofolate metabolism.

Authors: R J Pollock; S Kaufman
Journal: J Neurochem Date: 1978-07 Impact factor: 5.372

5. Further studies on tryptophan hydroxylase in rat brainstem and beef pineal.

Authors: E Jequier; D S Robinson; W Lovenberg; A Sjoerdsma
Journal: Biochem Pharmacol Date: 1969-05 Impact factor: 5.858

Review 6. Phenylketonuria and its variants.

Authors: S Kaufman
Journal: Adv Hum Genet Date: 1983

7. [Biopterin synthesis defects: complete deficiencies (reductase and synthetase)].

Authors: J P Harpey
Journal: Arch Fr Pediatr Date: 1983

8. Letter: A new molecular defect in phenylketonuria.

Authors: K Bartholome
Journal: Lancet Date: 1974-12-28 Impact factor: 79.321

9. Two new tetrahydropterin intermediates in the adrenal medullary de novo biosynthesis of tetrahydrobiopterin.

Authors: G K Smith; C A Nichol
Journal: Biochem Biophys Res Commun Date: 1984-05-16 Impact factor: 3.575

10. Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria.

Authors: S Kaufman; S Berlow; G K Summer; S Milstien; J D Schulman; S Orloff; S Spielberg; S Pueschel
Journal: N Engl J Med Date: 1978-09-28 Impact factor: 91.245

15 in total

1. Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia.

Authors: L Bonafé; B Thöny; J M Penzien; B Czarnecki; N Blau
Journal: Am J Hum Genet Date: 2001-07-06 Impact factor: 11.025

Review 2. Folates and psychiatric disorders. Clinical potential.

Authors: R Crellin; T Bottiglieri; E H Reynolds
Journal: Drugs Date: 1993-05 Impact factor: 9.546

Review 3. Restless legs syndrome and pregnancy: a review.

Authors: Prachaya Srivanitchapoom; Sanjay Pandey; Mark Hallett
Journal: Parkinsonism Relat Disord Date: 2014-04-08 Impact factor: 4.891

Review 4. Role of folic acid in nitric oxide bioavailability and vascular endothelial function.

Authors: Anna E Stanhewicz; W Larry Kenney
Journal: Nutr Rev Date: 2017-01 Impact factor: 7.110

5. Queuosine deficiency in eukaryotes compromises tyrosine production through increased tetrahydrobiopterin oxidation.

Authors: Tatsiana Rakovich; Coilin Boland; Ilana Bernstein; Vimbai M Chikwana; Dirk Iwata-Reuyl; Vincent P Kelly
Journal: J Biol Chem Date: 2011-04-12 Impact factor: 5.157

6. Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease.

Authors: Holger Cario; Desirée E C Smith; Henk Blom; Nenad Blau; Harald Bode; Karlheinz Holzmann; Ulrich Pannicke; Karl-Peter Hopfner; Eva-Maria Rump; Zuleya Ayric; Elisabeth Kohne; Klaus-Michael Debatin; Yvo Smulders; Klaus Schwarz
Journal: Am J Hum Genet Date: 2011-02-11 Impact factor: 11.025

Review 7. Tetrahydrobiopterin biosynthesis, regeneration and functions.

Authors: B Thöny; G Auerbach; N Blau
Journal: Biochem J Date: 2000-04-01 Impact factor: 3.857

8. Methylfolate modulates potassium evoked neuro-secretion: evidence for a role at the pteridine cofactor level of tyrosine 3-hydroxylase.

Authors: M D Lucock; M Green; M I Levene
Journal: Neurochem Res Date: 1995-06 Impact factor: 3.996

Review 9. Folate for depressive disorders.

Authors: M J Taylor; S Carney; J Geddes; G Goodwin
Journal: Cochrane Database Syst Rev Date: 2003

Review 10. Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics.

Authors: Emily J Tsai; David A Kass
Journal: Pharmacol Ther Date: 2009-03-21 Impact factor: 12.310