Literature DB >> 17840922

INTERACTION BETWEEN CRYSTALLINE PENICILLIN AND HUMAN PLASMA PROTEINS.

B F Chow, C M McKee.   

Abstract

Penicillin combines with human serum albumin, as demonstrated by dialysis experiments. Unlike the sulfonamfide-albumin complex, the penicillin-albumin possesses antibiotic activity. Such a complex can be freed of unbound penicillin by repeated precipitation at 50 per cent. alcohol and obtained as a dried powder. Mouse excretion studies indicated that the penicillin-albumin complex was excreted more slowly than the sodium salt of penicillin.

Entities:  

Year:  1945        PMID： 17840922     DOI： 10.1126/science.101.2612.67

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  16 in total

1.  [The binding of penicillin by serum albumin].

Authors:  K OEFF; S RUST; E SCHWARZ; H J WEISE
Journal:  Klin Wochenschr       Date:  1955-05-01

2.  [Transport and binding in the blood; study with paper electrophoresis and radioactive indicators: Fe 55/59, Cu 64, Co 56/57, Mn 52, Ga 67, S 35 and J 131].

Authors:  W HORST
Journal:  Klin Wochenschr       Date:  1954-10-15

3.  [Detection of precipitating antibodies against penicillin and streptomycin].

Authors:  F SCHEIFFARTH; G BERG; H L MERCK
Journal:  Klin Wochenschr       Date:  1953-11-15

4.  [Paper electrophoresis of blood proteins and antibiotics].

Authors:  H KUTZIM
Journal:  Klin Wochenschr       Date:  1952-09-15

5.  The prophylactic use of antibiotics in cell culture.

Authors:  I Kuhlmann
Journal:  Cytotechnology       Date:  1995-06       Impact factor: 2.058

6.  The Relation of Protein Binding to the Pharmacology and Antibacterial Activity of Penicillins X, G, Dihydro F, and K.

Authors:  R Tompsett; S Shultz; W McDermott
Journal:  J Bacteriol       Date:  1947-05       Impact factor: 3.490

7.  Studies on Penicillinase: III. The Effect of Antipenicillinase on Penicillin-resistant Organisms.

Authors:  R D Housewright; R J Henry
Journal:  J Bacteriol       Date:  1947-02       Impact factor: 3.490

8.  Studies on Penicillin in Blood: I. The Effects of Serum and Serum Filtrates upon the Growth of Staphylococcus aureus.

Authors:  E H Frieden; C N Frazier
Journal:  J Bacteriol       Date:  1945-09       Impact factor: 3.490

9.  The Effect of Human Serum on the Dilution Bioassay of Penicillins G, X, and K.

Authors:  H Eagle; H A Tucker
Journal:  J Bacteriol       Date:  1948-07       Impact factor: 3.490

10.  Controversial Points in Ocular Penicillin Therapy.

Authors:  L Von Sallmann
Journal:  Trans Am Ophthalmol Soc       Date:  1947
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