Literature DB >> 17839440

(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity.

E DE Clercq, J Descamps, P DE Somer, A Holyacute.   

Abstract

(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.

Entities:  

Year:  1978        PMID： 17839440     DOI： 10.1126/science.200.4341.563

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

1.  Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent.

Authors:  D F Smee; H A Alaghamandan; H B Cottam; B S Sharma; W B Jolley; R K Robins
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

2.  Hypomethylating drugs efficiently decrease cytosine methylation in telomeric DNA and activate telomerase without affecting telomere lengths in tobacco cells.

Authors:  Eva Majerová; Miloslava Fojtová; Iva Mozgová; Miroslava Bittová; Jiří Fajkus
Journal:  Plant Mol Biol       Date:  2011-08-25       Impact factor: 4.076

3.  Erythro-9-(2-hydroxy-3-nonyl)adenine as a specific inhibitor of herpes simplex virus replication in the presence and absence of adenosine analogues.

Authors:  T W North; S S Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

Review 4.  Approved Antiviral Drugs over the Past 50 Years.

Authors:  Erik De Clercq; Guangdi Li
Journal:  Clin Microbiol Rev       Date:  2016-07       Impact factor: 26.132

Review 5.  A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.

Authors:  Tanuja N Gengiah; Cheryl Baxter; Leila E Mansoor; Ayesha Bm Kharsany; Salim S Abdool Karim
Journal:  Expert Opin Investig Drugs       Date:  2012-03-07       Impact factor: 6.206

Review 6.  Specific targets for antiviral drugs.

Authors:  E De Clercq
Journal:  Biochem J       Date:  1982-07-01       Impact factor: 3.857

7.  Quantum chemical calculation of the (S)-9-(2,3-dihydroxypropyl)adenine molecule.

Authors:  Z Havlas; H Hrebabecký; J Beránek
Journal:  Nucleic Acids Res       Date:  1980-12-20       Impact factor: 16.971

Review 8.  Adenosine deaminase inhibitors: their role in chemotherapy and immunosuppression.

Authors:  R I Glazer
Journal:  Cancer Chemother Pharmacol       Date:  1980       Impact factor: 3.333

9.  In vitro activity of cefmetazole, cefotetan, amoxicillin-clavulanic acid, and other antimicrobial agents against anaerobic bacteria from endometrial cultures of women with pelvic infections.

Authors:  M J Ohm-Smith; R L Sweet
Journal:  Antimicrob Agents Chemother       Date:  1987-09       Impact factor: 5.191

10.  Inhibition of rotaviruses by selected antiviral substances: mechanisms of viral inhibition and in vivo activity.

Authors:  D F Smee; R W Sidwell; S M Clark; B B Barnett; R S Spendlove
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191
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