Literature DB >> 1782976

A lack of effect of captopril on platelet aggregation in patients with congestive heart failure.

I F Gow1, A D Flapan, M Morris, E Davies, B C Williams, P L Padfield, T R Shaw, C R Edwards.   

Abstract

We have studied the acute and chronic effects of an ACE inhibitor (captopril) on platelet function and the renin-angiotensin system in patients with congestive heart failure. Plasma concentrations of angiotensin II fell significantly after a single dose of captopril (25 mg) and during long-term treatment with captopril (2 weeks, 75 mg/day). Plasma renin activity increased significantly after both the single and repeated doses. Captopril did not affect ADP-induced platelet aggregation or concentrations. It seems unlikely that circulating angiotensin II affects ADP-induced platelet aggregation in patients with congestive heart failure.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1782976     DOI： 10.1007/BF00280105

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  22 in total

1.  Treatment of hypertension with captopril: preservation of regional blood flow and reduced platelet aggregation.

Authors:  I M James; E J Dickenson; W Burgoyne; J Y Jeremy; M A Barradas; D P Mikhailidis; P Dandona
Journal:  J Hum Hypertens       Date:  1988-06       Impact factor: 3.012

2.  A double blind placebo controlled crossover study of prostacyclin in man.

Authors:  G A FitzGerald; L A Friedman; I Miyamori; J O'Grady; P J Lewis
Journal:  Life Sci       Date:  1979-08-20       Impact factor: 5.037

3.  Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men.

Authors:  A Szczeklik; R J Gryglewski; R Nizankowski; J Musiał; R Pietoń; J Mruk
Journal:  Pharmacol Res Commun       Date:  1978-06

4.  Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.

Authors:  E Haber; T Koerner; L B Page; B Kliman; A Purnode
Journal:  J Clin Endocrinol Metab       Date:  1969-10       Impact factor: 5.958

5.  Release of a prostaglandin E-like substance from canine kidney by bradykinin.

Authors:  J C McGiff; N A Terragno; K U Malik; A J Lonigro
Journal:  Circ Res       Date:  1972-07       Impact factor: 17.367

6.  Plasma free captopril concentrations during short and long term treatment with oral captopril for heart failure.

Authors:  T R Shaw; F M Duncan; B C Williams; E Crichton; S A Thomson; J R Davis; M Rademaker; C R Edwards
Journal:  Br Heart J       Date:  1985-08

7.  Measurement of plasma angiotensin II.

Authors:  J J Morton; D J Webb
Journal:  Clin Sci (Lond)       Date:  1985-04       Impact factor: 6.124

8.  Potentiation of adrenaline-induced platelet aggregation by angiotensin II.

Authors:  Y A Ding; D E MacIntyre; C J Kenyon; P F Semple
Journal:  Thromb Haemost       Date:  1985-10-30       Impact factor: 5.249

9.  A specific orally active inhibitor of angiotensin-converting enzyme in man.

Authors:  R K Ferguson; G A Turini; H R Brunner; H Gavras; D N McKinstry
Journal:  Lancet       Date:  1977-04-09       Impact factor: 79.321

10.  Platelet release and thromboxane synthesis in symptomatic coronary artery disease.

Authors:  A C de Boer; A G Turpie; R W Butt; R V Johnston; E Genton
Journal:  Circulation       Date:  1982-08       Impact factor: 29.690
View more
  1 in total

1.  The sensitivity of human blood platelets to the aggregating agent ADP during different dietary sodium intakes in healthy men.

Authors:  I F Gow; M Dockrell; C R Edwards; A Elder; J Grieve; G Kane; P L Padfield; C J Waugh; B C Williams
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.