Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms.

Literature DB >> 17828756

Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms.

Abstract

Biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 17828756 DOI： 10.1002/jps.21176

Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534

Keyword Cloud
Cited

37 in total

1. Reversible blocking of amino groups of octreotide for the inhibition of formation of acylated peptide impurities in poly(lactide-co-glycolide) delivery systems.

Authors: Jae Hwa Ahn; Eun Ji Park; Hye Suk Lee; Kang Choon Lee; Dong Hee Na
Journal: AAPS PharmSciTech Date: 2011-09-21 Impact factor: 3.246

2. Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity.

Authors: Satomi Onoue; Kazuki Kuriyama; Atsushi Uchida; Takahiro Mizumoto; Shizuo Yamada
Journal: Pharm Res Date: 2011-02-02 Impact factor: 4.200

Review 3. Stability of protein pharmaceuticals: an update.

Authors: Mark Cornell Manning; Danny K Chou; Brian M Murphy; Robert W Payne; Derrick S Katayama
Journal: Pharm Res Date: 2010-02-09 Impact factor: 4.200

4. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates.

Authors: Gary W Ashley; Jeff Henise; Ralph Reid; Daniel V Santi
Journal: Proc Natl Acad Sci U S A Date: 2013-01-23 Impact factor: 11.205

5. Novel thermosensitive pentablock copolymers for sustained delivery of proteins in the treatment of posterior segment diseases.

Authors: Sulabh P Patel; Ravi Vaishya; Xiaoyan Yang; Dhananjay Pal; Ashim K Mitra
Journal: Protein Pept Lett Date: 2014 Impact factor: 1.890

Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms.

1. Reversible blocking of amino groups of octreotide for the inhibition of formation of acylated peptide impurities in poly(lactide-co-glycolide) delivery systems.

2. Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity.

Review 3. Stability of protein pharmaceuticals: an update.

4. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates.

5. Novel thermosensitive pentablock copolymers for sustained delivery of proteins in the treatment of posterior segment diseases.

6. Identification of immune factors regulating antitumor immunity using polymeric vaccines with multiple adjuvants.

7. Poly(lactic-co-glycolic) acid-controlled-release systems: experimental and modeling insights.

8. Acylation of exenatide by glycolic acid and its anti-diabetic activities in db/db mice.

9. Inhibition of peptide acylation in PLGA microspheres with water-soluble divalent cationic salts.

10. Synthesis of poly(propylene fumarate).