Literature DB >> 17828434

Myo-inositol-1-phosphate (MIP) synthase inhibition: in-vivo study in rats.

H Einat1, F Tian, R H Belmaker, J W Frost.   

Abstract

Lithium and valproate are the prototypic mood stabilizers and have diverse structures and targets. Both drugs influence inositol metabolism. Lithium inhibits IMPase and valproate inhibits MIP synthase. This study shows that MIP synthase inhibition does not replicate or augment the effects of lithium in the inositol sensitive pilocarpine-induced seizures model. This lack of effects may stem from the low contribution of de-novo synthesis to cellular inositol supply or to the inhibition of the de-novo synthesis by lithium itself.

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Year:  2007        PMID： 17828434     DOI： 10.1007/s00702-007-0807-4

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  18 in total

Review 1.  Anti-bipolar therapy: mechanism of action of lithium.

Authors:  R S Jope
Journal:  Mol Psychiatry       Date:  1999-03       Impact factor: 15.992

Review 2.  The Albert Lasker Medical Awards. Inositol trisphosphate, calcium, lithium, and cell signaling.

Authors:  M J Berridge
Journal:  JAMA       Date:  1989-10-06       Impact factor: 56.272

3.  Effects of systemically administered lithium on phosphoinositide metabolism in rat brain, kidney, and testis.

Authors:  W R Sherman; L Y Munsell; B G Gish; M P Honchar
Journal:  J Neurochem       Date:  1985-03       Impact factor: 5.372

4.  Nordidemnin potently inhibits inositol uptake in cultured astrocytes and dose-dependently augments lithium's proconvulsant effect in vivo.

Authors:  M Wolfson; H Einat; Y Bersudsky; V Berkin; R H Belmaker; L Hertz
Journal:  J Neurosci Res       Date:  2000-04-01       Impact factor: 4.164

Review 5.  Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited.

Authors:  A J Harwood
Journal:  Mol Psychiatry       Date:  2005-01       Impact factor: 15.992

6.  Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.

Authors:  O Kofman; W R Sherman; V Katz; R H Belmaker
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

Review 7.  Signaling networks in the pathophysiology and treatment of mood disorders.

Authors:  Todd D Gould; Husseini K Manji
Journal:  J Psychosom Res       Date:  2002-08       Impact factor: 3.006

8.  The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.

Authors:  Haim Einat; Peixiong Yuan; Todd D Gould; Jianling Li; JianHua Du; Lei Zhang; Husseini K Manji; Guang Chen
Journal:  J Neurosci       Date:  2003-08-13       Impact factor: 6.167

Review 9.  Myo-inositol attenuates two specific behavioral effects of acute lithium in rats.

Authors:  O Kofman; R H Belmaker; N Grisaru; C Alpert; I Fuchs; V Katz; O Rigler
Journal:  Psychopharmacol Bull       Date:  1991

10.  The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases.

Authors:  Lewis L Judd; Hagop S Akiskal
Journal:  J Affect Disord       Date:  2003-01       Impact factor: 4.839
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  3 in total

1.  Inhibitory effects of N-valproyl-L-tryptophan on high potassium, low calcium and low magnesium-induced CA1 hippocampal epileptiform bursting activity in rat brain slices.

Authors:  Pierangelo Sardo; Valerio Rizzo; Simonetta Friscia; Fabio Carletti; Viviana De Caro; Anna Lisa Scaturro; Giulia Giandalia; Libero Italo Giannola; Giuseppe Ferraro
Journal:  J Neural Transm (Vienna)       Date:  2012-05-10       Impact factor: 3.575

2.  The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.

Authors:  Pishan Chang; Benoit Orabi; Rania M Deranieh; Manik Dham; Oliver Hoeller; Jakob A Shimshoni; Boris Yagen; Meir Bialer; Miriam L Greenberg; Matthew C Walker; Robin S B Williams
Journal:  Dis Model Mech       Date:  2011-08-29       Impact factor: 5.758

3.  IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.

Authors:  Y Sade; L Toker; N Z Kara; H Einat; S Rapoport; D Moechars; G T Berry; Y Bersudsky; G Agam
Journal:  Transl Psychiatry       Date:  2016-12-06       Impact factor: 6.222
  3 in total

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