Literature DB >> 17828275

CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1.

Ikuko Hayashi1, Michael J Plevin, Mitsuhiko Ikura.   

Abstract

CLIP170 and p150(Glued) localize to the plus ends of growing microtubules. Using crystallography and NMR, we show that autoinhibitory interactions within CLIP170 use the same binding determinants as CLIP170's intermolecular interactions with p150(Glued). These interactions have both similar and distinct features when compared with the p150(Glued)-EB1 complex. Our data thus demonstrate that regulation of microtubule dynamics by plus end-tracking proteins (+TIPs) occurs through direct competition between homologous binding interfaces.

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Year:  2007        PMID： 17828275     DOI： 10.1038/nsmb1299

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  22 in total

Review 1.  Tubulin modifications and their cellular functions.

Authors:  Jennetta W Hammond; Dawen Cai; Kristen J Verhey
Journal:  Curr Opin Cell Biol       Date:  2008-01-15       Impact factor: 8.382

2.  Internal dynamics of dynactin CAP-Gly is regulated by microtubules and plus end tracking protein EB1.

Authors:  Si Yan; Huilan Zhang; Guangjin Hou; Shubbir Ahmed; John C Williams; Tatyana Polenova
Journal:  J Biol Chem       Date:  2014-12-01       Impact factor: 5.157

Review 3.  The chemical complexity of cellular microtubules: tubulin post-translational modification enzymes and their roles in tuning microtubule functions.

Authors:  Christopher P Garnham; Antonina Roll-Mecak
Journal:  Cytoskeleton (Hoboken)       Date:  2012-04-26

4.  Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein.

Authors:  Christian Duellberg; Martina Trokter; Rupam Jha; Indrani Sen; Michel O Steinmetz; Thomas Surrey
Journal:  Nat Cell Biol       Date:  2014-07-06       Impact factor: 28.824

5.  In vivo roles of the basic domain of dynactin p150 in microtubule plus-end tracking and dynein function.

Authors:  Xuanli Yao; Jun Zhang; Henry Zhou; Eric Wang; Xin Xiang
Journal:  Traffic       Date:  2011-12-18       Impact factor: 6.215

6.  Minimal plus-end tracking unit of the cytoplasmic linker protein CLIP-170.

Authors:  Kamlesh K Gupta; Benjamin A Paulson; Eric S Folker; Blake Charlebois; Alan J Hunt; Holly V Goodson
Journal:  J Biol Chem       Date:  2008-12-13       Impact factor: 5.157

7.  Mapping multivalency in the CLIP-170-EB1 microtubule plus-end complex.

Authors:  Yaodong Chen; Ping Wang; Kevin C Slep
Journal:  J Biol Chem       Date:  2018-11-19       Impact factor: 5.157

8.  CLIP-170-dependent capture of membrane organelles by microtubules initiates minus-end directed transport.

Authors:  Alexis J Lomakin; Irina Semenova; Ilya Zaliapin; Pavel Kraikivski; Elena Nadezhdina; Boris M Slepchenko; Anna Akhmanova; Vladimir Rodionov
Journal:  Dev Cell       Date:  2009-09       Impact factor: 12.270

9.  Characterization of DCTN1 genetic variability in neurodegeneration.

Authors:  C Vilariño-Güell; C Wider; A I Soto-Ortolaza; S A Cobb; J M Kachergus; B H Keeling; J C Dachsel; M M Hulihan; D W Dickson; Z K Wszolek; R J Uitti; N R Graff-Radford; B F Boeve; K A Josephs; B Miller; K B Boylan; K Gwinn; C H Adler; J O Aasly; F Hentati; A Destée; A Krygowska-Wajs; M-C Chartier-Harlin; O A Ross; R Rademakers; M J Farrer
Journal:  Neurology       Date:  2009-06-09       Impact factor: 9.910

10.  Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy.

Authors:  Si Yan; Changmiao Guo; Guangjin Hou; Huilan Zhang; Xingyu Lu; John Charles Williams; Tatyana Polenova
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-10       Impact factor: 11.205
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