Literature DB >> 17827772

Alpha-glucosidase inhibitors from Millettia conraui.

Alembert Tiabou Tchinda1, Shamsun Nahar Khan, Victorine Fuendjiep, François Ngandeu, Annie Ngono Ngane, Muhammad Iqbal Choudhary.   

Abstract

A new geranylated isoflavone, 7-O-geranyl-6-methoxypseudobaptigenin (1) was isolated from the stem barks of Millettia conraui, along with known compounds 5-methoxydurmillone (2), conrauinone A (3), beta-amyrine (4), sitosterol (5), 3-O-beta-D-glucopyranosyl sitosterol (6) and n-docosanol (7). Compounds 1 and 4 showed a significant alpha-glucosidase inhibitory activity. The structures of the compounds were determined by analysis of their spectroscopic data.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17827772     DOI: 10.1248/cpb.55.1402

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  3 in total

1.  Antidiabetic property of Symplocos cochinchinensis is mediated by inhibition of alpha glucosidase and enhanced insulin sensitivity.

Authors:  Kalathookunnel Antony Antu; Mariam Philip Riya; Arvind Mishra; Karunakaran S Anilkumar; Chandrasekharan K Chandrakanth; Akhilesh K Tamrakar; Arvind K Srivastava; K Gopalan Raghu
Journal:  PLoS One       Date:  2014-09-03       Impact factor: 3.240

2.  In silico identification of potential inhibitors of key SARS-CoV-2 3CL hydrolase (Mpro) via molecular docking, MMGBSA predictive binding energy calculations, and molecular dynamics simulation.

Authors:  M Iqbal Choudhary; Muniza Shaikh; Atia- Tul-Wahab; Atta- Ur-Rahman
Journal:  PLoS One       Date:  2020-07-24       Impact factor: 3.240

3.  'Mechanistic insights into 5-lipoxygenase inhibition by active principles derived from essential oils of Curcuma species: Molecular docking, ADMET analysis and molecular dynamic simulation study.

Authors:  Ayushman Gadnayak; Budheswar Dehury; Ananya Nayak; Sudipta Jena; Ambika Sahoo; Pratap Chandra Panda; Asit Ray; Sanghamitra Nayak
Journal:  PLoS One       Date:  2022-07-22       Impact factor: 3.752

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.