| Literature DB >> 17827664 |
Shu-Wei Yang1, Ronald Mierzwa, Joseph Terracciano, Mahesh Patel, Vincent Gullo, Nicole Wagner, Bahige Baroudy, Mohindar Puar, Tze-Ming Chan, Min Chu.
Abstract
A novel fungal secondary metabolite, Sch 213766 was isolated from the fungal fermentation broth of Chaetomium globosum as the chemokine receptor CCR-5 inhibitor and shown to be the methyl ester of the previously described tetramic acid Sch 210972 on the basis of UV, MS and NMR spectral data analyses. Sch213766 exhibited an IC(50) value of 8.6 muM in the CCR-5 receptor in vitro binding assay.Entities:
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Year: 2007 PMID： 17827664 DOI： 10.1038/ja.2007.67
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649