| Literature DB >> 17827014 |
Min Teng1, Michael D Johnson, Christine Thomas, Dan Kiel, James N Lakis, Tim Kercher, Shelley Aytes, Jarek Kostrowicki, Dilip Bhumralkar, Larry Truesdale, John May, Ulla Sidelman, Janos T Kodra, Anker Steen Jørgensen, Preben Houlberg Olesen, Johannes Cornelis de Jong, Peter Madsen, Carsten Behrens, Ingrid Pettersson, Lotte Bjerre Knudsen, Jens J Holst, Jesper Lau.
Abstract
Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.Entities:
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Year: 2007 PMID： 17827014 DOI： 10.1016/j.bmcl.2007.06.086
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823