Literature DB >> 17827006

N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.

Wenwei Huang1, Wei Zheng, Daniel J Urban, James Inglese, Ellen Sidransky, Christopher P Austin, Craig J Thomas.   

Abstract

A series of 1,3,5-triazine-2,4,6-triamines were prepared and analyzed as inhibitors of glucocerebrosidase. Synthesis, structure activity relationships and the selectivity of chosen analogues against related sugar hydrolases enzymes are described.

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Year:  2007        PMID： 17827006      PMCID： PMC2083578          DOI： 10.1016/j.bmcl.2007.08.050

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

1.  Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.

Authors:  P J Hajduk; J Dinges; J M Schkeryantz; D Janowick; M Kaminski; M Tufano; D J Augeri; A Petros; V Nienaber; P Zhong; R Hammond; M Coen; B Beutel; L Katz; S W Fesik
Journal:  J Med Chem       Date:  1999-09-23       Impact factor: 7.446

Review 2.  The cell biology of lysosomal storage disorders.

Authors:  Anthony H Futerman; Gerrit van Meer
Journal:  Nat Rev Mol Cell Biol       Date:  2004-07       Impact factor: 94.444

3.  Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents.

Authors:  Sanjay Babu Katiyar; Kumkum Srivastava; S K Puri; Prem M S Chauhan
Journal:  Bioorg Med Chem Lett       Date:  2005-11-15       Impact factor: 2.823

Review 4.  Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease.

Authors:  A R Sawkar; W D'Haeze; J W Kelly
Journal:  Cell Mol Life Sci       Date:  2006-05       Impact factor: 9.261

5.  Rational design and synthesis of highly potent beta-glucocerebrosidase inhibitors.

Authors:  Xiaoxiang Zhu; Kamlesh A Sheth; Shihong Li; Hui-Hwa Chang; Jian-Qiang Fan
Journal:  Angew Chem Int Ed Engl       Date:  2005-12-01       Impact factor: 15.336

6.  Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.

Authors:  Wei Zheng; Janak Padia; Daniel J Urban; Ajit Jadhav; Ozlem Goker-Alpan; Anton Simeonov; Ehud Goldin; Douglas Auld; Mary E LaMarca; James Inglese; Christopher P Austin; Ellen Sidransky
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-01       Impact factor: 11.205

7.  Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles.

Authors:  Anu R Sawkar; Sara L Adamski-Werner; Wei-Chieh Cheng; Chi-Huey Wong; Ernest Beutler; Klaus-Peter Zimmer; Jeffery W Kelly
Journal:  Chem Biol       Date:  2005-11

8.  Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease.

Authors:  Anu R Sawkar; Wei-Chieh Cheng; Ernest Beutler; Chi-Huey Wong; William E Balch; Jeffery W Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-14       Impact factor: 11.205

9.  The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.

Authors:  Katerina Leftheris; Gulzar Ahmed; Ran Chan; Alaric J Dyckman; Zahid Hussain; Kan Ho; John Hynes; Jeffrey Letourneau; Wei Li; Shuqun Lin; Axel Metzger; Kevin J Moriarty; Chris Riviello; Yvonne Shimshock; James Wen; John Wityak; Stephen T Wrobleski; Hong Wu; Junjun Wu; Madhuri Desai; Kathleen M Gillooly; Tsung H Lin; Derek Loo; Kim W McIntyre; Sidney Pitt; Ding Ren Shen; David J Shuster; Rosemary Zhang; David Diller; Arthur Doweyko; John Sack; Jack Baldwin; Joel Barrish; John Dodd; Ian Henderson; Steve Kanner; Gary L Schieven; Maria Webb
Journal:  J Med Chem       Date:  2004-12-02       Impact factor: 7.446

10.  Replacement therapy for inherited enzyme deficiency--macrophage-targeted glucocerebrosidase for Gaucher's disease.

Authors:  N W Barton; R O Brady; J M Dambrosia; A M Di Bisceglie; S H Doppelt; S C Hill; H J Mankin; G J Murray; R I Parker; C E Argoff
Journal:  N Engl J Med       Date:  1991-05-23       Impact factor: 91.245
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  7 in total

1.  Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.

Authors:  Samarjit Patnaik; Wei Zheng; Jae H Choi; Omid Motabar; Noel Southall; Wendy Westbroek; Wendy A Lea; Arash Velayati; Ehud Goldin; Ellen Sidransky; William Leister; Juan J Marugan
Journal:  J Med Chem       Date:  2012-06-08       Impact factor: 7.446

Review 2.  NIMH initiatives to facilitate collaborations among industry, academia, and government for the discovery and clinical testing of novel models and drugs for psychiatric disorders.

Authors:  Linda S Brady; Lois Winsky; Wayne Goodman; Mary Ellen Oliveri; Ellen Stover
Journal:  Neuropsychopharmacology       Date:  2008-09-17       Impact factor: 7.853

3.  Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators.

Authors:  Jianbin Zheng; Long Chen; Michael Schwake; Richard B Silverman; Dimitri Krainc
Journal:  J Med Chem       Date:  2016-09-06       Impact factor: 7.446

4.  β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site.

Authors:  Jianbin Zheng; Long Chen; Owen S Skinner; Daniel Ysselstein; Jonathan Remis; Peter Lansbury; Renato Skerlj; Michael Mrosek; Ursula Heunisch; Stephan Krapp; Joel Charrow; Michael Schwake; Neil L Kelleher; Richard B Silverman; Dimitri Krainc
Journal:  J Am Chem Soc       Date:  2018-04-30       Impact factor: 15.419

5.  An efficient chemical approach to bispecific antibodies and antibodies of high valency.

Authors:  Julia I Gavrilyuk; Ulrich Wuellner; Syed Salahuddin; Rajib K Goswami; Subhash C Sinha; Carlos F Barbas
Journal:  Bioorg Med Chem Lett       Date:  2009-05-18       Impact factor: 2.823

Review 6.  The pilot phase of the NIH Chemical Genomics Center.

Authors:  Craig J Thomas; Douglas S Auld; Ruili Huang; Wenwei Huang; Ajit Jadhav; Ronald L Johnson; William Leister; David J Maloney; Juan J Marugan; Sam Michael; Anton Simeonov; Noel Southall; Menghang Xia; Wei Zheng; James Inglese; Christopher P Austin
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

7.  Ambroxol as a pharmacological chaperone for mutant glucocerebrosidase.

Authors:  Inna Bendikov-Bar; Gali Maor; Mirella Filocamo; Mia Horowitz
Journal:  Blood Cells Mol Dis       Date:  2012-11-14       Impact factor: 3.039
  7 in total

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