Literature DB >> 17826814

Correlations between differences in amino-terminal sequences and different hemolytic activity of sticholysins.

Eduardo M Cilli1, Fábio T Pigossi, Edson Crusca, Uris Ros, Diana Martinez, Maria E Lanio, Carlos Alvarez, Shirley Schreier.   

Abstract

Sticholysins I and II (St I and St II) are cytolysins produced by the sea anemone Stichodactyla helianthus. In spite of their 93% sequence homology, St II is more hemolytic against human erythrocytes than St I. In order to establish the possible causes of this difference, we studied the hemolytic activity of synthetic peptides containing sequences from the N-termini of both proteins. The results demonstrated that the differences in hemolytic activity of the toxins could be ascribed at least partly to differences in their N-termini.

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Year:  2007        PMID： 17826814     DOI： 10.1016/j.toxicon.2007.07.013

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  10 in total

1.  The membranotropic activity of N-terminal peptides from the pore-forming proteins sticholysin I and II is modulated by hydrophobic and electrostatic interactions as well as lipid composition.

Authors:  Uris Ros; Lohans Pedrera; DaylÍn Diaz; Juan C De Karam; Tatiane P Sudbrack; Pedro A Valiente; Diana MartÍnez; Eduardo M Cilli; Fabiola Pazos; Rosangela Itri; Maria E Lanio; Shirley Schreier; Carlos Ávarez
Journal:  J Biosci       Date:  2011-12       Impact factor: 1.826

2.  Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha.

Authors:  E N Lorenzón; G F Cespedes; E F Vicente; L G Nogueira; T M Bauab; M S Castro; E M Cilli
Journal:  Antimicrob Agents Chemother       Date:  2012-03-05       Impact factor: 5.191

3.  Membrane Remodeling by the Lytic Fragment of SticholysinII: Implications for the Toroidal Pore Model.

Authors:  Haydee Mesa-Galloso; Pedro A Valiente; Mario E Valdés-Tresanco; Raquel F Epand; Maria E Lanio; Richard M Epand; Carlos Alvarez; D Peter Tieleman; Uris Ros
Journal:  Biophys J       Date:  2019-09-20       Impact factor: 4.033

Review 4.  Biophysical and biochemical strategies to understand membrane binding and pore formation by sticholysins, pore-forming proteins from a sea anemone.

Authors:  Carlos Alvarez; Uris Ros; Aisel Valle; Lohans Pedrera; Carmen Soto; Yadira P Hervis; Sheila Cabezas; Pedro A Valiente; Fabiola Pazos; Maria E Lanio
Journal:  Biophys Rev       Date:  2017-08-29

5.  Mutagenesis and functional analysis of the pore-forming toxin HALT-1 from Hydra magnipapillata.

Authors:  Yvonne Jing Mei Liew; Wai Tuck Soh; William Febry Jiemy; Jung Shan Hwang
Journal:  Toxins (Basel)       Date:  2015-02-03       Impact factor: 4.546

6.  Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties.

Authors:  Cláudia S Oliveira; Cleópatra A S Caldeira; Rafaela Diniz-Sousa; Dolores L Romero; Silvana Marcussi; Laura A Moura; André L Fuly; Cicília de Carvalho; Walter L G Cavalcante; Márcia Gallacci; Maeli Dal Pai; Juliana P Zuliani; Leonardo A Calderon; Andreimar M Soares
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2018-08-28

7.  Dynamics and conformational studies of TOAC spin labeled analogues of Ctx(Ile(21))-Ha peptide from Hypsiboas albopunctatus.

Authors:  Eduardo F Vicente; Luis Guilherme M Basso; Graziely F Cespedes; Esteban N Lorenzón; Mariana S Castro; Maria José S Mendes-Giannini; Antonio José Costa-Filho; Eduardo M Cilli
Journal:  PLoS One       Date:  2013-04-09       Impact factor: 3.240

8.  Dissecting the mechanism of action of actinoporins. Role of the N-terminal amphipathic α-helix in membrane binding and pore activity of sticholysins I and II.

Authors:  Gustavo P B Carretero; Eduardo F Vicente; Eduardo M Cilli; Carlos M Alvarez; Håvard Jenssen; Shirley Schreier
Journal:  PLoS One       Date:  2018-08-30       Impact factor: 3.240

9.  GA-Hecate antiviral properties on HCV whole cycle represent a new antiviral class and open the door for the development of broad spectrum antivirals.

Authors:  Mariana Nogueira Batista; Paulo Ricardo da Silva Sanches; Bruno Moreira Carneiro; Ana Cláudia Silva Braga; Guilherme Rodrigues Fernandes Campos; Eduardo Maffud Cilli; Paula Rahal
Journal:  Sci Rep       Date:  2018-09-25       Impact factor: 4.379

10.  Antimicrobial activity of RP-1 peptide conjugate with ferrocene group.

Authors:  Natalia C S Costa; Julia P Piccoli; Norival A Santos-Filho; Leandro C Clementino; Ana M Fusco-Almeida; Sarah R De Annunzio; Carla R Fontana; Juliane B M Verga; Silas F Eto; João M Pizauro-Junior; Marcia A S Graminha; Eduardo M Cilli
Journal:  PLoS One       Date:  2020-03-26       Impact factor: 3.240
  10 in total

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