Literature DB >> 17826740

Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.

Mamta Rawat1, Chantale Johnson, Vanessa Cadiz, Yossef Av-Gay.   

Abstract

The role of mycothiol in mycobacteria was examined by comparative analysis of mutants disrupted in the four known genes encoding the protein machinery needed for mycothiol biosynthesis. These mutants were sensitive to acid stress, antibiotic stress, alkylating stress, and oxidative stress indicating that mycothiol and mycothiol-dependent enzymes protect the mycobacterial cell against attack from various different types of stresses and toxic agents.

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Year:  2007        PMID： 17826740     DOI： 10.1016/j.bbrc.2007.08.142

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  25 in total

1.  Inactivation of the organic hydroperoxide stress resistance regulator OhrR enhances resistance to oxidative stress and isoniazid in Mycobacterium smegmatis.

Authors:  Sankaralingam Saikolappan; Kishore Das; Subramanian Dhandayuthapani
Journal:  J Bacteriol       Date:  2014-10-13       Impact factor: 3.490

2.  Compounds with Potential Activity against Mycobacterium tuberculosis.

Authors:  B Baker; C Carolis; C Sao Emani; M J Williams; I J Wiid
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

3.  Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis.

Authors:  Carine Sao Emani; Monique J Williams; Ian J Wiid; Nicholas F Hiten; Albertus J Viljoen; Ray-Dean D Pietersen; Paul D van Helden; Bienyameen Baker
Journal:  Antimicrob Agents Chemother       Date:  2013-04-29       Impact factor: 5.191

4.  Mass Spectrometric Analysis of Mycothiol levels in Wild-Type and Mycothiol Disulfide Reductase Mutant Mycobacterium smegmatis.

Authors:  Cynthia M Holsclaw; Wilson B Muse; Kate S Carroll; Julie A Leary
Journal:  Int J Mass Spectrom       Date:  2011-08-15       Impact factor: 1.986

5.  Host-pathogen redox dynamics modulate Mycobacterium tuberculosis pathogenesis.

Authors:  Hayden T Pacl; Vineel P Reddy; Vikram Saini; Krishna C Chinta; Adrie J C Steyn
Journal:  Pathog Dis       Date:  2018-07-01       Impact factor: 3.166

6.  Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants.

Authors:  Philong Ta; Nancy Buchmeier; Gerald L Newton; Mamta Rawat; Robert C Fahey
Journal:  J Bacteriol       Date:  2011-02-18       Impact factor: 3.490

7.  Analysis of mutants disrupted in bacillithiol metabolism in Staphylococcus aureus.

Authors:  Arishma Rajkarnikar; Andrew Strankman; Shayla Duran; Derek Vargas; Alexandra A Roberts; Kathryn Barretto; Heather Upton; Christopher J Hamilton; Mamta Rawat
Journal:  Biochem Biophys Res Commun       Date:  2013-04-22       Impact factor: 3.575

8.  Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity.

Authors:  Melissa Richard-Greenblatt; Horacio Bach; John Adamson; Sandra Peña-Diaz; Wu Li; Adrie J C Steyn; Yossef Av-Gay
Journal:  J Biol Chem       Date:  2015-07-30       Impact factor: 5.157

9.  Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.

Authors:  Vikram Saini; Bridgette M Cumming; Loni Guidry; Dirk A Lamprecht; John H Adamson; Vineel P Reddy; Krishna C Chinta; James H Mazorodze; Joel N Glasgow; Melissa Richard-Greenblatt; Anaximandro Gomez-Velasco; Horacio Bach; Yossef Av-Gay; Hyungjin Eoh; Kyu Rhee; Adrie J C Steyn
Journal:  Cell Rep       Date:  2016-01-07       Impact factor: 9.423

Review 10.  Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.

Authors:  Gerald L Newton; Nancy Buchmeier; Robert C Fahey
Journal:  Microbiol Mol Biol Rev       Date:  2008-09       Impact factor: 11.056
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