| Literature DB >> 17826092 |
Neil W Johnson1, Marcus Semones, Jerry L Adams, Michael Hansbury, Jim Winkler.
Abstract
In an effort to understand the effect of N-alkylation of triarylimidazoles on Tie2 inhibition, ortho-substituted C-2 aryl analogs were synthesized to investigate the effect of different torsion angles on potency. This exercise resulted in the identification of a potent and selective tetrasubstituted imidazole that was efficacious in an animal model of angiogenesis.Entities:
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Year: 2007 PMID： 17826092 DOI： 10.1016/j.bmcl.2007.08.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823