| Literature DB >> 17825578 |
U Hofmann1, S Heuer, K Meder, J Boehler, V Lange, T Quaschning, G Ertl, A Bonz.
Abstract
Considerable experimental evidence has accumulated over the past years that proinflammatory cytokines, especially TNF-alpha and IL-1beta, impair myocardial function in different animal species. On the other hand, several prospective clinical trials studying TNF-alpha antagonist in patients with chronic heart failure were not able to demonstrate a benefit. As there might be a relevant species-related discrepancy, we intended to prove our previous results demonstrating impaired myocardial economy after exogenous administration of recombinant TNF-alpha in rat myocardium. In the present study, both TNF-alpha and IL-1beta not only revealed an immediate negative inotropic effect but also increased specific oxygen demand in human right-atrial myocardium. Enhanced oxygen consumption was not caused by an elevated basal metabolism but an impaired economy of contraction. Our results suggest that proinflammatory cytokines have a considerable effect on myocardial mechano-energetic parameters in human myocardium as well.Entities:
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Year: 2007 PMID： 17825578 DOI： 10.1016/j.cyto.2007.07.185
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861