| Literature DB >> 17825431 |
Cynthia Chester Cardoso1, Alejandra Nóbrega Martinez, Pedro Edson Moreira Guimarães, Camila Teixeira Mendes, Antônio Guilherme Pacheco, Rosane Barbosa de Oliveira, Rosane Magda Brandão Teles, Ximena Illarramendi, Elizabeth Pereira Sampaio, Euzenir Nunes Sarno, Emmanuel Dias-Neto, Milton Ozório Moraes.
Abstract
Leprosy is the major cause of non-traumatic neuropathy. Herein, we investigated the role of ninjurin 1, an adhesion molecule involved in nerve regeneration in leprosy. Our results demonstrated that M. leprae stimulates in vitro up-regulation of ninjurin mRNA in cultured Schwann and blood cells as well as in vivo mRNA and protein expression in leprosy nerve biopsies. A polymorphism (asp110ala) was investigated in a case-control study (1123 individuals) and no association was found with leprosy per se or with disseminated forms. Nevertheless, ala110 was associated with functional nerve impairment (OR=2.42; p=0.02 for ala/ala) and with lower mRNA levels. Our data suggests that asp110ala could be a valuable genetic marker of nerve damage in leprosy.Entities:
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Year: 2007 PMID： 17825431 DOI： 10.1016/j.jneuroim.2007.07.015
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478