| Literature DB >> 17825429 |
Atsuki Fukushima1, Tamaki Sumi, Ken Fukuda, Naoki Kumagai, Teruo Nishida, Tomohide Yamazaki, Hisaya Akiba, Ko Okumura, Hideo Yagita, Hisayuki Ueno.
Abstract
B7-H3 negatively regulates Th1-mediated immune responses. Here, we aimed to investigate whether B7-H3 is involved in the development of murine experimental allergic conjunctivitis (EC), which is predominantly mediated by Th2 cells. Intraperitoneal injection of anti-B7-H3 Ab during the induction phase of EC significantly augmented the severity of EC evaluated as conjunctival eosinophil numbers and Ag-induced IL-5 production by splenocytes. Injection of anti-B7-H3 Ab during the effector phase of EC did not significantly affect the severity of EC. In addition, transfer of Ag-primed splenocytes treated with anti-B7-H3 Ab in vitro did not significantly affect the severity of EC, compared to the splenocytes treated with the control Ab. Thus, regulation of EC by blocking of B7-H3 was observed during the induction phase but not the effector phase. Moreover, this study provides a new notion that B7-H3 regulates not only Th1-mediated but also Th2-mediated immune reactions.Entities:
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Year: 2007 PMID： 17825429 DOI： 10.1016/j.imlet.2007.07.011
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685