| Literature DB >> 17825301 |
Jiri Neuzil1, Emma Swettenham, Xiu-Fang Wang, Lan-Feng Dong, Michael Stapelberg.
Abstract
Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was suppressed by pre-treating MM cells with alpha-tocopheryl succinate (alpha-TOS), which inhibited FGF2 secretion by inducing mitochondria-dependent generation of reactive oxygen species. The role of FGF2 was confirmed by its down-regulation by treating MM cells with siRNA, abolishing EC proliferation and wound healing enhancement afforded by MM cells. We conclude that alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling.Entities:
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Year: 2007 PMID： 17825301 DOI： 10.1016/j.febslet.2007.08.051
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124