BACKGROUND: Proton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra. OBJECTIVE: To create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours. MATERIALS AND METHODS: Single-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results. RESULTS: A total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho <0.75 and mIns/NAA <2.1 separated all the medulloblastomas from the ependymomas. CONCLUSION: Peak height ratios from short-echo-time MRS can accurately predict the histopathology of childhood cerebellar tumours.
BACKGROUND: Proton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra. OBJECTIVE: To create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours. MATERIALS AND METHODS: Single-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results. RESULTS: A total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho <0.75 and mIns/NAA <2.1 separated all the medulloblastomas from the ependymomas. CONCLUSION: Peak height ratios from short-echo-time MRS can accurately predict the histopathology of childhood cerebellar tumours.
Authors: Arzu Kovanlikaya; Ashok Panigrahy; Mark D Krieger; Ignacio Gonzalez-Gomez; Nilesh Ghugre; J Gordon McComb; Floyd H Gilles; Marvin D Nelson; Stefan Blüml Journal: Radiology Date: 2005-09 Impact factor: 11.105
Authors: Roula Hourani; Alena Horská; Sait Albayram; Larry J Brant; Elias Melhem; Kenneth J Cohen; Peter C Burger; John D Weingart; Benjamin Carson; Moody D Wharam; Peter B Barker Journal: J Magn Reson Imaging Date: 2006-02 Impact factor: 4.813
Authors: Anne Laprie; Andrea Pirzkall; Daphne A Haas-Kogan; Soonmee Cha; Anuradha Banerjee; Terry P Le; Ying Lu; Sarah Nelson; Tracy R McKnight Journal: Int J Radiat Oncol Biol Phys Date: 2005-05-01 Impact factor: 7.038
Authors: Mark J Albers; Mark D Krieger; Ignacio Gonzalez-Gomez; Floyd H Gilles; J Gordon McComb; Marvin D Nelson; Stefan Blüml Journal: Magn Reson Med Date: 2005-01 Impact factor: 4.668
Authors: A Devos; L Lukas; J A K Suykens; L Vanhamme; A R Tate; F A Howe; C Majós; A Moreno-Torres; M van der Graaf; C Arús; S Van Huffel Journal: J Magn Reson Date: 2004-09 Impact factor: 2.229
Authors: A Aria Tzika; Loukas G Astrakas; Maria K Zarifi; David Zurakowski; Tina Young Poussaint; Liliana Goumnerova; Nancy J Tarbell; Peter McL Black Journal: Cancer Date: 2004-03-15 Impact factor: 6.860
Authors: K Koral; S Zhang; L Gargan; W Moore; B Garvey; M Fiesta; M Seymour; L Yang; D Scott; N Choudhury Journal: AJNR Am J Neuroradiol Date: 2013-06-20 Impact factor: 3.825
Authors: Karen A Manias; Lisa M Harris; Nigel P Davies; Kal Natarajan; Lesley MacPherson; Katharine Foster; Marie-Anne Brundler; Darren R Hargrave; Geoffery S Payne; Martin O Leach; Paul S Morgan; Dorothee Auer; Tim Jaspan; Theodoros N Arvanitis; Richard G Grundy; Andrew C Peet Journal: Pediatr Radiol Date: 2018-07-30
Authors: Pamela Franco; Irene Huebschle; Carl Philipp Simon-Gabriel; Karam Dacca; Oliver Schnell; Juergen Beck; Hansjoerg Mast; Horst Urbach; Urs Wuertemberger; Marco Prinz; Jonas A Hosp; Daniel Delev; Irina Mader; Dieter Henrik Heiland Journal: Cancers (Basel) Date: 2021-05-17 Impact factor: 6.639