Literature DB >> 17823744

[Cisplatin ototoxicity: series of cases].

Luiz Alberto Alves Mota1, Marília Silvino Iglésias Melo, Maria Heloísa Pedrosa Santos, Kátia Maria Gomes de Albuquerque, Cristiana de Lima Tavares.   

Abstract

OBJECTIVE: To evaluate the clinic and audiometric evolution of individuals who underwent chemotherapy with cisplatin.
METHODS: Four volunteers, all women, between 38 and 69 years of age were descriptively evaluated. All did otorinolaryngoiatric exam and audiometric evaluation with tonal and speech audiometric and impedance tests before and after treatment with cisplatin. In addition, all were subjectively evaluated pre- and post-chemotherapy by a questionnaire.
RESULTS: One volunteer did not present auditory disorders. Three volunteers presented bilateral hearing loss, mild to moderate in 6 kHz and 8 kHz frequencies, after chemotherapy with cisplatin. All volunteers who developed hearing loss after treatment also presented tinnitus.
CONCLUSION: Since cisplatin is considered ototoxic, all individuals undergoing chemotherapy with this drug must be submitted to audiometric monitoring for early diagnosis of a hearing loss.

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Year:  2007        PMID: 17823744     DOI: 10.1590/s0104-42302007000400026

Source DB:  PubMed          Journal:  Rev Assoc Med Bras (1992)        ISSN: 0104-4230            Impact factor:   1.209


  2 in total

1.  Causes of tinnitus in patients referred to ENT clinic of Imam Khomeini hospital in Urmia, 2012-2013.

Authors:  R Samarei; N Fatholahi
Journal:  Glob J Health Sci       Date:  2014-09-18

2.  Effects of subchronic inhalation exposure to an organophosphorus insecticide compound containing dichlorvos on wistar rats' otoacoustic emissions.

Authors:  Aléxia Dos Reis; Eduarda Oliveira Cunha; Marina Tuerlinckx Costa Valle; Márcia Salgado Machado; Eliane Dallegrave
Journal:  Braz J Otorhinolaryngol       Date:  2020-05-19
  2 in total

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