BACKGROUND: Kaposi's sarcoma (KS) is a lymphangioproliferative tumour. Therapy of KS depends on the characteristics of the disease, especially area and growth rate of lesions, and patient condition. Currently symptomatic resectable lesions are excised, whereas more advanced disease and unresectable lesions are treated with radiotherapy. If a large area or internal organs are affected or other treatments fail, chemotherapy is used. Recently some authors have reported their encouraging experience in the use of thalidomide in patients with AIDS-related KS. OBJECTIVE: To evaluate the efficacy of thalidomide in 3 patients with non-AIDS-related KS. METHODS: Two patients with classic widespread cutaneous and 1 with iatrogenic cutaneous and visceral KS were treated with thalidomide (100 mg/day) for 12 months. RESULTS: In all 3 patients partial remission was evident after 4 months of thalidomide therapy; in 2 out of 3 complete remission was achieved after 12 months of treatment. CONCLUSIONS: Our results seem to confirm the utility of thalidomide in the treatment of non-AIDS-related KS. Copyright 2007 S. Karger AG, Basel.
BACKGROUND:Kaposi's sarcoma (KS) is a lymphangioproliferative tumour. Therapy of KS depends on the characteristics of the disease, especially area and growth rate of lesions, and patient condition. Currently symptomatic resectable lesions are excised, whereas more advanced disease and unresectable lesions are treated with radiotherapy. If a large area or internal organs are affected or other treatments fail, chemotherapy is used. Recently some authors have reported their encouraging experience in the use of thalidomide in patients with AIDS-related KS. OBJECTIVE: To evaluate the efficacy of thalidomide in 3 patients with non-AIDS-related KS. METHODS: Two patients with classic widespread cutaneous and 1 with iatrogenic cutaneous and visceral KS were treated with thalidomide (100 mg/day) for 12 months. RESULTS: In all 3 patients partial remission was evident after 4 months of thalidomide therapy; in 2 out of 3 complete remission was achieved after 12 months of treatment. CONCLUSIONS: Our results seem to confirm the utility of thalidomide in the treatment of non-AIDS-related KS. Copyright 2007 S. Karger AG, Basel.
Authors: Erin G Reid; Kelly Shimabukuro; Page Moore; Richard F Ambinder; Jack D Bui; Semi Han; Otoniel Martínez-Maza; Dirk P Dittmer; David Aboulafia; Elizabeth Yu Chiao; Toby Maurer; Robert Baiocchi; Ronald Mitsuyasu; William Wachsman Journal: Clin Cancer Res Date: 2022-06-13 Impact factor: 13.801
Authors: David A Davis; Suraj Mishra; Holda A Anagho; Ashley I Aisabor; Prabha Shrestha; Victoria Wang; Yuki Takamatsu; Kenji Maeda; Hiroaki Mitsuya; Jerome B Zeldis; Robert Yarchoan Journal: Oncotarget Date: 2017-05-17