BACKGROUND: Thalidomide has antiangiogenic and immunomodulatory properties and has recently been used in the management of human malignancies. Several studies have suggested its interest for treating AIDS-related Kaposi's sarcoma. OBJECTIVES: This study aimed to assess the efficacy and toxicity of thalidomide, an antiangiogenic agent, for the treatment of non-HIV-related Kaposi's sarcoma. METHODS: Eleven patients were included in this retrospective study conducted in the Department of Dermatology of Saint Louis, Paris, between 2000 and 2003. Among them, 2 were immunosuppressed (1 renal transplant recipient and 1 patient with microscopic polyangiitis treated by oral steroids) with stable immunosuppressive regimens during the past 6 months. The median daily thalidomide dosage was 100 mg and the median duration of drug treatment was 16 weeks. RESULTS: Three patients achieved a partial response and 4 had a stable disease. Although no grade 3 or 4 was observed, 3 (27%) out of 11 patients prematurely discontinued thalidomide because of grade 1 sensory neuropathy (paresthesia) and vertigo. CONCLUSIONS: Our results show a true although modest interest of thalidomide in non-HIV-related Kaposi's sarcoma and prompt us to evaluate less toxic thalidomide analogues for this indication. Copyright 2007 S. Karger AG, Basel.
BACKGROUND:Thalidomide has antiangiogenic and immunomodulatory properties and has recently been used in the management of humanmalignancies. Several studies have suggested its interest for treating AIDS-related Kaposi's sarcoma. OBJECTIVES: This study aimed to assess the efficacy and toxicity of thalidomide, an antiangiogenic agent, for the treatment of non-HIV-related Kaposi's sarcoma. METHODS: Eleven patients were included in this retrospective study conducted in the Department of Dermatology of Saint Louis, Paris, between 2000 and 2003. Among them, 2 were immunosuppressed (1 renal transplant recipient and 1 patient with microscopic polyangiitis treated by oral steroids) with stable immunosuppressive regimens during the past 6 months. The median daily thalidomide dosage was 100 mg and the median duration of drug treatment was 16 weeks. RESULTS: Three patients achieved a partial response and 4 had a stable disease. Although no grade 3 or 4 was observed, 3 (27%) out of 11 patients prematurely discontinued thalidomide because of grade 1 sensory neuropathy (paresthesia) and vertigo. CONCLUSIONS: Our results show a true although modest interest of thalidomide in non-HIV-related Kaposi's sarcoma and prompt us to evaluate less toxic thalidomide analogues for this indication. Copyright 2007 S. Karger AG, Basel.
Authors: Marios Grigoriou; Konstantinia E Kofina; Aristeidis Ioannidis; Domniki K Gerasimidou; Christoforos Efthymiadis; Thomas Zaramboukas Journal: Am J Case Rep Date: 2017-07-26
Authors: David A Davis; Suraj Mishra; Holda A Anagho; Ashley I Aisabor; Prabha Shrestha; Victoria Wang; Yuki Takamatsu; Kenji Maeda; Hiroaki Mitsuya; Jerome B Zeldis; Robert Yarchoan Journal: Oncotarget Date: 2017-05-17