| Literature DB >> 1782308 |
E Mathai1, A Arora, M Cafferkey, C T Keane, C O'Morain.
Abstract
Bile reflux gastritis occurs in the absence of Helicobacter pylori (H. pylori). The aim of this study was to see if the bile acids cheno or ursodeoxycholic acid affected the growth or adherence of H. pylori in vitro. Twenty-seven strains growth were inhibited by 0.1% chenodeoxycholic acid whereas only 11 out of the 27 were inhibited by 0.1% ursodeoxycholic acid. Growth was totally inhibited by a combination of 0.05% chenodeoxycholic acid +0.05% ursodeoxycholic acid. Chenodeoxycholic acid was a more effective inhibitor of adherence in that the number inhibited and percentage inhibition were greater than with ursodeoxycholic acid. Bile salts might be useful in the treatment of H. pylori infection.Entities:
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Year: 1991 PMID： 1782308 DOI： 10.1111/j.1365-2036.1991.tb00533.x
Source DB: PubMed Journal: Aliment Pharmacol Ther ISSN： 0269-2813 Impact factor: 8.171