Literature DB >> 17822905

Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates.

Ahmed Kamal1, R Ramu, Venkatesh Tekumalla, G B Ramesh Khanna, Madan S Barkume, Aarti S Juvekar, Surekha M Zingde.   

Abstract

A series of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as anticancer activity. Some of these molecules have shown significant anticancer activity in a number of cancer cell lines.

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Year:  2007        PMID： 17822905     DOI： 10.1016/j.bmc.2007.08.026

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

Review 1.  Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines.

Authors:  Barbara Gerratana
Journal:  Med Res Rev       Date:  2010-06-13       Impact factor: 12.944

2.  The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.

Authors:  Ashley A Fisher; Matthew T Labenski; Srinivas Malladi; John D Chapman; Shawn B Bratton; Terrence J Monks; Serrine S Lau
Journal:  Toxicol Sci       Date:  2011-04-28       Impact factor: 4.849

3.  Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants.

Authors:  H Zubair; H Y Khan; A Sohail; S Azim; M F Ullah; A Ahmad; F H Sarkar; S M Hadi
Journal:  Cell Death Dis       Date:  2013-06-06       Impact factor: 8.469
  3 in total

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