Literature DB >> 17822294

Naamidines H and I, cytotoxic imidazole alkaloids from the Indonesian marine sponge Leucetta chagosensis.

Sachiko Tsukamoto1, Tetsuro Kawabata, Hikaru Kato, Tomihisa Ohta, Henki Rotinsulu, Remy E P Mangindaan, Rob W M van Soest, Kazuyo Ukai, Hisayoshi Kobayashi, Michio Namikoshi.   

Abstract

Two new imidazole alkaloids, naamidines H ( 1) and I ( 2), were isolated from the marine sponge Leucetta chagosensis, collected in North Sulawesi, Indonesia. The compounds ( 1 and 2) showed cytotoxicity against HeLa cells with IC50 values of 5.6 and 15 microg/mL, respectively.

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Year:  2007        PMID： 17822294     DOI： 10.1021/np070246i

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Total synthesis and cytotoxicity of Leucetta alkaloids.

Authors:  Panduka B Koswatta; Sabha Kasiri; Jayanta K Das; Arunoday Bhan; Heather M Lima; Beatriz Garcia-Barboza; Nicole N Khatibi; Muhammed Yousufuddin; Subhrangsu S Mandal; Carl J Lovely
Journal:  Bioorg Med Chem       Date:  2017-01-20       Impact factor: 3.641

2.  Two new imidazole alkaloids from Leucetta chagosensis sponge.

Authors:  Wafaa H B Hassan; Areej M Al-Taweel; Peter Proksch
Journal:  Saudi Pharm J       Date:  2009-11-10       Impact factor: 4.330

3.  In vitro and in vivo antineoplastic activity of a novel bromopyrrole and its potential mechanism of action.

Authors:  Sheng Xiong; Hui-dan Pang; Jun Fan; Feng Ge; Xiao-xia Yang; Qiu-ying Liu; Xiao-jian Liao; Shi-hai Xu
Journal:  Br J Pharmacol       Date:  2010-01-08       Impact factor: 8.739

Review 4.  Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review.

Authors:  Ahmed M Elissawy; Ebrahim Soleiman Dehkordi; Negin Mehdinezhad; Mohamed L Ashour; Pardis Mohammadi Pour
Journal:  Biomolecules       Date:  2021-02-10

5.  An iodine/DMSO-catalyzed sequential one-pot approach to 2,4,5-trisubstituted-1H-imidazoles from α-methylene ketones.

Authors:  Janeeka Jayram; Vineet Jeena
Journal:  RSC Adv       Date:  2018-11-07       Impact factor: 3.361

6.  Information exploration system for sickle cell disease and repurposing of hydroxyfasudil.

Authors:  Magbubah Essack; Aleksandar Radovanovic; Vladimir B Bajic
Journal:  PLoS One       Date:  2013-06-10       Impact factor: 3.240

7.  Fusagerins A-F, New Alkaloids from the Fungus Fusarium sp.

Authors:  Hao Wen; Yan Li; Xingzhong Liu; Wencai Ye; Xinsheng Yao; Yongsheng Che
Journal:  Nat Prod Bioprospect       Date:  2015-09-02

Review 8.  Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates.

Authors:  Fauzia Izzati; Mega Ferdina Warsito; Asep Bayu; Anggia Prasetyoputri; Akhirta Atikana; Linda Sukmarini; Siti Irma Rahmawati; Masteria Yunovilsa Putra
Journal:  Molecules       Date:  2021-03-27       Impact factor: 4.411
  8 in total

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