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Literature DB >> 17817846

"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide.

J N Pitts, D M Lokensgard, P S Ripley, K A VAN Cauwenberghe, L VAN Vaeck, S D Shaffer, A J Thill, W L Belser.

Abstract

Benzo[a]pyrene deposited on a glass fiber filter reacts rapidly in the dark or light with ambient levels of ozone to yield a mixture of products that display strong direct mutagenicity in the Ames assay. The major stable contributor to this activity has been identified as benzo[a]pyrene-4,5-oxide, a DNA-binding metabolite in biological systems, known to be a strong direct mutagen with Salmonella typhimurium strain TA98.

Entities: Chemical Species

Year: 1980 PMID： 17817846 DOI： 10.1126/science.210.4476.1347

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

12 in total

1. Effects of ozonation on mutagenic activity of polycyclic aromatic hydrocarbons.

Authors: B Fouillet; P Chambon; R Chambon; M Castegnaro; N Weill
Journal: Bull Environ Contam Toxicol Date: 1991-07 Impact factor: 2.151

2. Exploring data quality for some inorganic and organic constituents of inhalable particulate matter (PM10).

Authors: R Harkov; A Greenberg; F Darack; L McGeorge; C Pietarinen
Journal: Environ Monit Assess Date: 1987-07 Impact factor: 2.513

3. Effects of environmental conditions on polycyclic aromatic hydrocarbons and mutagenicity of airborne particulate matter.

Authors: N Takeda; K Teranishi
Journal: Bull Environ Contam Toxicol Date: 1986-05 Impact factor: 2.151

4. Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease.

Authors: Emily M Wong; William F Walby; Dennis W Wilson; Fern Tablin; Edward S Schelegle
Journal: Toxicol Sci Date: 2018-05-01 Impact factor: 4.849

5. Assessment of benzo(a)pyrene-equivalent carcinogenicity and mutagenicity of residential indoor versus outdoor polycyclic aromatic hydrocarbons exposing young children in New York City.

Authors: Kyung Hwa Jung; Beizhan Yan; Steven N Chillrud; Frederica P Perera; Robin Whyatt; David Camann; Patrick L Kinney; Rachel L Miller
Journal: Int J Environ Res Public Health Date: 2010-04-27 Impact factor: 3.390

"Atmospheric" Epoxidation of Benzo[a]pyrene by Ozone: Formation of the Metabolite Benzo[a]pyrene-4,5-Oxide.

1. Effects of ozonation on mutagenic activity of polycyclic aromatic hydrocarbons.

2. Exploring data quality for some inorganic and organic constituents of inhalable particulate matter (PM10).

3. Effects of environmental conditions on polycyclic aromatic hydrocarbons and mutagenicity of airborne particulate matter.

4. Ultrafine Particulate Matter Combined With Ozone Exacerbates Lung Injury in Mature Adult Rats With Cardiovascular Disease.

5. Assessment of benzo(a)pyrene-equivalent carcinogenicity and mutagenicity of residential indoor versus outdoor polycyclic aromatic hydrocarbons exposing young children in New York City.

6. Organic composition in the dry season rainwater of Guangzhou, China.

7. The fate of airborne polycyclic organic matter.

Review 8. Formation and fate of gaseous and particulate mutagens and carcinogens in real and simulated atmospheres.

9. Sampling of vehicle emissions for chemical analysis and biological testing.

10. Transformation of polycyclic aromatic hydrocarbons during sampling.