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Literature DB >> 1781743

Effects of inhaled ethylene oxide on the lens glutathione redox cycle in rats.

Abstract

The effects of chronic ethylene oxide (EtO) inhalation on the lens glutathione redox cycle were investigated. When Wistar male rats were exposed to 500 ppm EtO for 6 h a day, 3 times a week for 13 weeks, glutathione reductase decreased significantly in the lens while glutathione peroxidase did not. Glutathione reductase activity decreased time dependently, by as much as 81% after 13 weeks. In spite of changes in the glutathione redox cycle, reduced and oxidized glutathione levels were not affected. Our results raise the possibility that EtO inhalation may produce a cataract via changes in the glutathione redox cycle.

Entities: Chemical Disease Gene Species

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Year: 1991 PMID： 1781743 DOI： 10.1007/bf01973725

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

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References

11 in total

1. Lipid peroxidation and the metabolism of glutathione in rat liver and brain following ethylene oxide inhalation.

Authors: T Katoh; K Higashi; N Inoue; I Tanaka
Journal: Toxicology Date: 1989-09 Impact factor: 4.221

2. Testicular toxicity and alterations of glutathione metabolism resulting from chronic inhalation of ethylene oxide in rats.

Authors: K Mori; M Kaido; K Fujishiro; N Inoue
Journal: Toxicol Appl Pharmacol Date: 1989-11 Impact factor: 4.219

Effects of inhaled ethylene oxide on the lens glutathione redox cycle in rats.

1. Lipid peroxidation and the metabolism of glutathione in rat liver and brain following ethylene oxide inhalation.

2. Testicular toxicity and alterations of glutathione metabolism resulting from chronic inhalation of ethylene oxide in rats.

3. Determination of serum proteins by means of the biuret reaction.

4. A fluorometric method for determination of oxidized and reduced glutathione in tissues.

5. Familial deficiency of glutathione reductase in human blood cells.

6. Glutathione peroxidase from bovine lens: a selenoenzyme.

7. Possible relationship of ethylene oxide exposure to cataract formation.

8. Ethylene oxide induces central-peripheral distal axonal degeneration of the lumbar primary neurones in rats.

9. Effects of chronic inhalation of ethylene oxide on lipid peroxidation and glutathione redox cycle in rat liver.

10. Glutathione metabolism in lenses of dogs and rabbits: activities of five enzymes.