Literature DB >> 1781029

Malignant transformation by mutant Rel proteins.

T D Gilmore1.   

Abstract

A newly described family of transcriptional regulatory proteins, the Rel family, has recently been the subject of much interest. The Rel family includes proteins known to be important in Drosophila development, replication of HIV-1, oncogenesis and general transcriptional control. Nevertheless, there is still much to be learned about their precise mechanism of action, including the process by which the original member of this family, v-Rel, malignantly transforms cells.

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Year:  1991        PMID： 1781029     DOI： 10.1016/0168-9525(91)90421-l

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  28 in total

1.  In vivo self-association of the Drosophila rel-protein dorsal.

Authors:  S Govind; A M Whalen; R Steward
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205

2.  Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.

Authors:  R Lin; P Beauparlant; C Makris; S Meloche; J Hiscott
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

3.  A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel.

Authors:  G Mosialos; P Hamer; A J Capobianco; R A Laursen; T D Gilmore
Journal:  Mol Cell Biol       Date:  1991-12       Impact factor: 4.272

4.  Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.

Authors:  D W White; G A Pitoc; T D Gilmore
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

5.  AP-1 factors play an important role in transformation induced by the v-rel oncogene.

Authors:  J Kralova; A S Liss; W Bargmann; H R Bose
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

6.  Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

Authors:  A Ray; K E Prefontaine
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

7.  The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner.

Authors:  G P Nolan; T Fujita; K Bhatia; C Huppi; H C Liou; M L Scott; D Baltimore
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

8.  High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors.

Authors:  C Legraverend; P Antonson; P Flodby; K G Xanthopoulos
Journal:  Nucleic Acids Res       Date:  1993-04-25       Impact factor: 16.971

9.  Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.

Authors:  K Isoda; C Nüsslein-Volhard
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

10.  Distribution of Xrel in the early Xenopus embryo: a cytoplasmic and nuclear gradient.

Authors:  E L Bearer
Journal:  Eur J Cell Biol       Date:  1994-04       Impact factor: 4.492
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