Literature DB >> 17808500

Spherical crystallization: direct spherical agglomeration of salicylic Acid crystals during crystallization.

Y Kawashima, M Okumura, H Takenaka.   

Abstract

Direct spherical agglomeration of salicylic acid crystals during crystallization is described. The needle-like salicylic acid crystals simultaneously form and agglomerate in a mixture of three partially miscible liquids, such as water, ethanol, and chloroform, with agitation. The agglomerates can be made directly into tablets because of their excellent flowability. Spherical crystallization could eliminate the usual separate agglomeration step after crystallization and may be adaptable to other pharmaceutical and chemical systems.

Entities:  

Year:  1982        PMID： 17808500     DOI： 10.1126/science.216.4550.1127

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Spherical agglomeration of mefenamic acid and nabumetone to improve micromeritics and solubility: a technical note.

Authors:  Chelakara L Viswanathan; Sushrut K Kulkarni; Dhanashri R Kolwankar
Journal:  AAPS PharmSciTech       Date:  2006-05-26       Impact factor: 3.246

2.  Materials engineering of solid-state dosage forms.

Authors:  Tonglei Li
Journal:  Pharm Res       Date:  2007-11-06       Impact factor: 4.200

Review 3.  How spherical crystallization improves direct tableting properties: a review.

Authors:  Maryam Maghsoodi
Journal:  Adv Pharm Bull       Date:  2012-08-15

4.  On the mechanism of agglomeration in suspension.

Authors:  Maryam Maghsoodi; Katayoun Derakhshandeh; Zahra Yari
Journal:  Adv Pharm Bull       Date:  2012-02-15

5.  Overcoming poor tabletability of pharmaceutical crystals by surface modification.

Authors:  Limin Shi; Changquan Calvin Sun
Journal:  Pharm Res       Date:  2011-06-28       Impact factor: 4.200

Review 6.  Role of solvents in improvement of dissolution rate of drugs: crystal habit and crystal agglomeration.

Authors:  Maryam Maghsoodi
Journal:  Adv Pharm Bull       Date:  2015-03-05

7.  Preparation of agglomerated crystals for direct tabletting and microencapsulation by the spherical crystallization technique with a continuous system.

Authors:  T Niwa; H Takeuchi; T Hino; A Itoh; Y Kawashima; K Kiuchi
Journal:  Pharm Res       Date:  1994-04       Impact factor: 4.200

8.  Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer.

Authors:  Maryam Maghsoodi; Ali Nokhodchi
Journal:  Adv Pharm Bull       Date:  2016-12-22

9.  Enhanced dissolution rate of felodipine using spherical agglomeration with Inutec SP1 by quasi emulsion solvent diffusion method.

Authors:  A R Tapas; P S Kawtikwar; D M Sakarkar
Journal:  Res Pharm Sci       Date:  2009-07

10.  Influence of excipients and processing conditions on the development of agglomerates of racecadotril by crystallo-co-agglomeration.

Authors:  Kevin Garala; Jaydeep Patel; Anjali Patel; Mihir Raval; Abhay Dharamsi
Journal:  Int J Pharm Investig       Date:  2012-10
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