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Literature DB >> 17805862

An unsaturated phosphonic acid analogue of phosphatidylethanolamine and its activity in blood-clotting systems.

D L Turner¹, M J Silver, R R Holburn, E Baczynski, A B Brown.

Abstract

An unsaturated phosphonolipid analogous to phosphatidylethanolamine,rac-dioleoylglyceryl(2-aminoethyl)phosphonate, was synthesized by a general method introduced by Baer for similar saturated substances. An improvement was made in the preparation of the phthalimidoethyl-phosphonic acid precursor.The phosphonolipid was purified by DEAE cellulose and silicic acid chromatography. It was tested by comparison with synthetic phosphatidyl (dioleoyl) ethanolamine and phosphatidyl(dilinoleoyl) ethanolamine in the Hicks-Pitney test and in a test for prothrombin conversion by using purified blood coagulation factors. In both tests it had more acceleratory activity than the synthetic phosphatidylethanolamines.

Entities: Chemical

Year: 1968 PMID： 17805862 DOI： 10.1007/BF02531193

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

24 in total

8. Phospholipid structure and thromboplastic activity. II. The fatty acid composition of the active phosphatidyl ethanolamines.

Authors: G ROUSER; D SCHLOREDT
Journal: Biochim Biophys Acta Date: 1958-04

9. The isolation of factor V from bovine plasma.

Authors: M P Esnouf; F Jobin
Journal: Biochem J Date: 1967-03 Impact factor: 3.857

10. Phospholipid structure and thromboplastic activity. I. The phosphatide fraction active in recalcified normal human plasma.

Authors: G ROUSER; S G WHITE; D SCHLOREDT
Journal: Biochim Biophys Acta Date: 1958-04

1 in total

1. The synthesis of phosphatidylethanolamine and phosphatidylserine containing acetylenic or cyclopropane fatty acids and the activity of these phosphatides in blood coagulation.

Authors: D L Turner; M J Silver; E Baczynski; R R Holburn; S F Herb; F E Luddy
Journal: Lipids Date: 1970-07 Impact factor: 1.880

1 in total

An unsaturated phosphonic acid analogue of phosphatidylethanolamine and its activity in blood-clotting systems.

1. THROMBOKINASE AS PRIME ACTIVATOR OF PROTHROMBIN: HISTORICAL PERSPECTIVES AND PRESENT STATUS.

2. THROMBOPLASTIC ACTIVITY OF PHOSPHATIDYLETHANOLAMINE FROM NATURAL AND SYNTHETIC SOURCES.

3. SYNTHESIS AND ACTIVITY IN BLOOD CLOTTING SYSTEMS OF UNSATURATED RACEMIC PHOSPHATIDYL SERINES.

4. PHOSPHOLIPID FRACTIONATION AND BLOOD CLOTTING.

5. DETERMINATION OF POLAR LIPIDS: QUANTITATIVE COLUMN AND THIN-LAYER CHROMATOGRAPHY.

6. Platelet phosphatides. Their fatty acid and aldehyde composition and activity in different clotting systems.

7. A correlation between surface charge and coagulant action of phospholipids.

8. Phospholipid structure and thromboplastic activity. II. The fatty acid composition of the active phosphatidyl ethanolamines.

9. The isolation of factor V from bovine plasma.

10. Phospholipid structure and thromboplastic activity. I. The phosphatide fraction active in recalcified normal human plasma.

1. The synthesis of phosphatidylethanolamine and phosphatidylserine containing acetylenic or cyclopropane fatty acids and the activity of these phosphatides in blood coagulation.