Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Agents affecting lipid metabolism. XXVI. Specificity of some inhibitors of the late stages of cholesterol biosynthesis.

Literature DB >> 17805713

Agents affecting lipid metabolism. XXVI. Specificity of some inhibitors of the late stages of cholesterol biosynthesis.

Abstract

The capacity of 22,25-DAC, AY-9944 and triparanol to inhibit cholesterol biosynthesis from three precursors, mevalonate, 7-dehydrocholesterol and desmosterol, has been studied in rat liver homogenates.Evidence is presented that, in vitro, 22,25-DAC, a potent inhibitor of the sterol Delta(24)-reductase, also inhibits the 7-dehydrocholesterol-Delta(7)-reductase system.

Entities: Chemical Species

Year: 1967 PMID： 17805713 DOI： 10.1007/BF02531992

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

18 in total

1. EFFECT OF 22,25-DIAZACHOLESTANOL ON SYNTHESIS OF CHOLESTEROL BY RAT LIVER HOMOGENATES.

Authors: D DVORNIK; M KRAML; J DUBUC
Journal: Proc Soc Exp Biol Med Date: 1964-06

2. AN AZASTEROL THAT INDUCES HYPOCHOLESTEROLEMIA IN RATS.

Authors: R E RANNEY; D L COOK; W E HAMBOURGER; R E COUNSELL
Journal: J Pharmacol Exp Ther Date: 1963-10 Impact factor: 4.030

3. AGENTS AFFECTING LIPID METABOLISM. XII. N,N'-DISUBSTITUTED CYCLOHEXANE-1,4-BIS(METHYLAMINES).

Authors: L G HUMBER
Journal: J Med Chem Date: 1964-11 Impact factor: 7.446

4. THE COMMON MODE OF ACTION OF THREE NEW CLASSES OF INHIBITORS OF CHOLESTEROL BIOSYNTHESIS.

Authors: G RODNEY; M L BLACK; O D BIRD
Journal: Biochem Pharmacol Date: 1965-04 Impact factor: 5.858

5. AGENTS AFFECTING LIPID METABOLISM. XV. BIOCHEMICAL STUDIES WITH THE CHOLESTEROL BIOSYNTHESIS INHIBITOR AY-9944 IN YOUNG AND MATURE RATS.

Authors: M L GIVNER; D DVORNIK
Journal: Biochem Pharmacol Date: 1965-04 Impact factor: 5.858

9. Agents affecting lipid metabolism. 28. A 7-dehydrocholesterol delta-7-reductase inhibitor (AY-9944) as tool in studies of delta-7-sterol metabolism.

Authors: D Dvornik; M Kraml; J F Bagli
Journal: Biochemistry Date: 1966-03 Impact factor: 3.162

10. The relationship between structure and activity in a novel series of serum cholesterol-lowering agents.

Authors: L G Humber; C I Chappel; A V Marton; M Kraml; J Dubuc
Journal: J Med Chem Date: 1966-05 Impact factor: 7.446

1 in total

1. HPLC analysis of desmosterol, 7-dehydrocholesterol, and cholesterol.

Authors: E H Goh; S M Colles; K D Otte
Journal: Lipids Date: 1989-07 Impact factor: 1.880