Literature DB >> 17804566

Modulation of acute and chronic inflammation of the lung by GITR and its ligand.

Giuseppe Nocentini1, Salvatore Cuzzocrea, Rodolfo Bianchini, Emanuela Mazzon, Carlo Riccardi.   

Abstract

Glucocorticoid-induced TNFR-related (GITR) protein, a member of the tumor necrosis factor receptor superfamily, is expressed in many components of the innate and adaptive immune system and modulates their activation following interaction with its ligand (GITRL). Here we review and discuss results described in previous publications where the role of the GITR/GITRL system in lung inflammation was evaluated using two experimental systems. We also discuss the proinflammatory role played by the GITR/GITRL system and the potential use of GITR fusion protein in inhibiting inflammation.

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Year:  2007        PMID： 17804566     DOI： 10.1196/annals.1381.040

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  5 in total

1.  Blockade of GITR-GITRL interaction maintains Treg function to prolong allograft survival.

Authors:  James I Kim; Samsher B Sonawane; Major K Lee; Seoung-Hoon Lee; Patrick E Duff; Daniel J Moore; Matthew R O'Connor; Moh-Moh Lian; Shaoping Deng; Yongwon Choi; Heidi Yeh; Andrew J Caton; James F Markmann
Journal:  Eur J Immunol       Date:  2010-05       Impact factor: 5.532

2.  Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours.

Authors:  Jinhua Piao; Yosuke Kamimura; Hideyuki Iwai; Yujia Cao; Keisuke Kikuchi; Masaaki Hashiguchi; Taro Masunaga; Hongsi Jiang; Kouichi Tamura; Shimon Sakaguchi; Miyuki Azuma
Journal:  Immunology       Date:  2009-08       Impact factor: 7.397

3.  GITR Blockade Facilitates Treg Mediated Allograft Survival.

Authors:  Samsher B Sonawane; James I Kim; Major K Lee; Seoung-Hoon Lee; Patrick E Duff; Daniel J Moore; Moh-Moh Lian; Shaoping Deng; Yongwon Choi; Heidi Yeh; Andrew J Caton; James F Markmann
Journal:  Transplantation       Date:  2009-11-27       Impact factor: 4.939

4.  Inflammatory mechanisms in the lung.

Authors:  B Moldoveanu; P Otmishi; P Jani; J Walker; X Sarmiento; J Guardiola; M Saad; Jerry Yu
Journal:  J Inflamm Res       Date:  2008-12-16

Review 5.  Reverse Signaling of Tumor Necrosis Factor Superfamily Proteins in Macrophages and Microglia: Superfamily Portrait in the Neuroimmune Interface.

Authors:  Won-Ha Lee; Donggun Seo; Su-Geun Lim; Kyoungho Suk
Journal:  Front Immunol       Date:  2019-02-19       Impact factor: 7.561
  5 in total

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