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Literature DB >> 17804244

Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells.

Yong Xia¹, Zhi-Wu Dong, Bao-Xiang Zhao, Xiao Ge, Ning Meng, Dong-Soo Shin, Jun-Ying Miao.

Abstract

A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives were synthesized, and the effects of all the compounds on A549 cell growth were investigated. The results showed that all the nine compounds had inhibitory effects on the growth of A549 cells and induced the cell apoptosis. The study on structure-activity relationships and prediction of lipophilicities of compounds showed that compounds with logP values in the range of 3.12-4.94 had more inhibitory effects on the growth of A549 cells.

Entities: Chemical Disease

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Year: 2007 PMID： 17804244 DOI： 10.1016/j.bmc.2007.08.021

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

17 in total

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Authors: Hong-Shui Lv; Yong-Sheng Xie; Wei-Yong Liu; Zhong-Liang Gong; Bao-Xiang Zhao
Journal: J Fluoresc Date: 2011-03-05 Impact factor: 2.217

Review 2. Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors: Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal: Molecules Date: 2018-01-12 Impact factor: 4.411

3. One-pot synthesis, biological evaluation, and docking study of new chromeno-annulated thiopyrano[2,3-c]pyrazoles.

Authors: Bhagyashri D Parmar; Tushar R Sutariya; Gaurangkumar C Brahmbhatt; Narsidas J Parmar; Rajni Kant; Vivek K Gupta; Prashant R Murumkar; Mayank Kumar Sharma; Mange Ram Yadav
Journal: Mol Divers Date: 2016-03-26 Impact factor: 2.943

4. Magnetically recoverable Fe₃O₄ nanocatalyst for the synthesis of biodynamically significant 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives and its DFT study.

Authors: Mohd Danish Ansari; Hozeyfa Sagir; Vijay B Yadav; Neetu Yadav; Ankit Verma; Sonam Shakya; Manjit Singh; I R Siddiqui
Journal: Mol Divers Date: 2022-10-07 Impact factor: 3.364

Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells.

1. Synthesis, X-ray crystal structures and optical properties of novel substituted pyrazoly 1,3,4-oxadiazole derivatives.

Review 2. Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

3. One-pot synthesis, biological evaluation, and docking study of new chromeno-annulated thiopyrano[2,3-c]pyrazoles.

4. Magnetically recoverable Fe₃O₄ nanocatalyst for the synthesis of biodynamically significant 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives and its DFT study.

5. Antimicrobial screening to molecular docking of newly synthesized ferrocenyl-substituted pyrazole.

6. Ethyl 5-(ethoxy-carbon-yl)-3-(4-methoxy-phen-yl)-1H-pyrazole-1-acetate.

7. 1-[(6-Chloro-3-pyrid-yl)meth-yl]-N-(4-ethoxy-phen-yl)-3-phenyl-1H-pyrazole-5-carboxamide.

8. 1-(4-tert-Butyl-benz-yl)-3-phenyl-1H-pyrazole-5-carboxylic acid.

9. Ethyl 1-(4-chloro-benz-yl)-3-phenyl-1H-pyrazole-5-carboxyl-ate.

10. 3-(4-Bromo-phen-yl)-1-(4-chloro-benz-yl)-1H-pyrazole-5-carbaldehyde.