| Literature DB >> 17804230 |
Shu-Wei Yang1, Tze-Ming Chan, Alexei Buevich, Tony Priestley, James Crona, John Reed, Amy E Wright, Mahesh Patel, Vincent Gullo, Guodong Chen, Birendra Pramanik, Min Chu.
Abstract
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish, Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (1) and Sch 725739 (2). Compound 1 was identified as the NaV1.8 inhibitor with IC(50) of approximately 9 microM. The purification and the structure elucidation of these two saponins are described.Entities:
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Year: 2007 PMID： 17804230 DOI： 10.1016/j.bmcl.2007.08.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823