| Literature DB >> 17804093 |
Nivedita Roy1, Aleyde Van Eynde, Lijs Beke, Mieke Nuytten, Mathieu Bollen.
Abstract
NIPP1 is a ubiquitously expressed nuclear protein that represses the transcription of targeted genes. Here we show that the transcriptional repression by NIPP1 is alleviated by the RNAi-mediated knockdown of EED and EZH2, two core components of the Polycomb Repressive Complex 2 (PRC2), and by the overexpression of a catalytically dead mutant of the histone methyltransferase EZH2. NIPP1 is present in a complex with EED and EZH2 in vivo and has distinct binding sites for these proteins. These data disclose an essential role for the PRC2 complex in the transcriptional repression by NIPP1.Entities:
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Year: 2007 PMID： 17804093 DOI： 10.1016/j.bbaexp.2007.07.004
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002