BACKGROUND: The diagnostic and prognostic importance of brachial artery flow-mediated dilation (BFMD) for cardiovascular disease (CVD) is not certain and associations between BFMD and recognized measures of atherosclerosis have not been well established. METHODS: We investigated cross-sectional and longitudinal correlations between repeated measures of BFMD and quantitative coronary artery angiographic (QCA) measurements of average percent diameter stenosis, number of lesions and minimum luminal diameter (MLD), and ultrasonographic measurement of carotid artery intima-media thickness (CIMT) in an ethnically diverse cohort of postmenopausal women (n=132) with coronary artery disease (CAD). Subjects were participants in a 3-year randomized, placebo-controlled clinical trial, testing the efficacy of hormone therapy on atherosclerosis progression. Associations between BFMD and QCA measures, and between BFMD and CIMT were examined using measurements from the same study visit. RESULTS:BFMD was significantly inversely correlated with coronary artery stenosis at baseline (beta=-1.21% [S.E.(beta)=0.38], p=0.002). BFMD levels significantly predicted rate of change in CIMT over the trial period (beta=-0.76 microm/year [S.E.(beta)=0.29], p=0.008). CONCLUSIONS: Physiological and anatomical measures of atherosclerosis are correlated among postmenopausal women with CAD, which provides some validation of BFMD as a measure of atherosclerosis in high-risk populations.
RCT Entities:
BACKGROUND: The diagnostic and prognostic importance of brachial artery flow-mediated dilation (BFMD) for cardiovascular disease (CVD) is not certain and associations between BFMD and recognized measures of atherosclerosis have not been well established. METHODS: We investigated cross-sectional and longitudinal correlations between repeated measures of BFMD and quantitative coronary artery angiographic (QCA) measurements of average percent diameter stenosis, number of lesions and minimum luminal diameter (MLD), and ultrasonographic measurement of carotid artery intima-media thickness (CIMT) in an ethnically diverse cohort of postmenopausal women (n=132) with coronary artery disease (CAD). Subjects were participants in a 3-year randomized, placebo-controlled clinical trial, testing the efficacy of hormone therapy on atherosclerosis progression. Associations between BFMD and QCA measures, and between BFMD and CIMT were examined using measurements from the same study visit. RESULTS: BFMD was significantly inversely correlated with coronary artery stenosis at baseline (beta=-1.21% [S.E.(beta)=0.38], p=0.002). BFMD levels significantly predicted rate of change in CIMT over the trial period (beta=-0.76 microm/year [S.E.(beta)=0.29], p=0.008). CONCLUSIONS: Physiological and anatomical measures of atherosclerosis are correlated among postmenopausal women with CAD, which provides some validation of BFMD as a measure of atherosclerosis in high-risk populations.
Authors: M Hashimoto; M Eto; M Akishita; K Kozaki; J Ako; K Iijima; S Kim; K Toba; M Yoshizumi; Y Ouchi Journal: Arterioscler Thromb Vasc Biol Date: 1999-11 Impact factor: 8.311
Authors: H N Hodis; W J Mack; R A Lobo; D Shoupe; A Sevanian; P R Mahrer; R H Selzer; C R Liu Cr; C H Liu Ch; S P Azen Journal: Ann Intern Med Date: 2001-12-04 Impact factor: 25.391
Authors: D M Herrington; L Fan; M Drum; W A Riley; B E Pusser; J R Crouse; G L Burke; M A McBurnie; T M Morgan; M A Espeland Journal: J Cardiovasc Risk Date: 2001-10
Authors: T Haraki; T Takegoshi; C Kitoh; T Wakasugi; T Saga; J-I Hirai; T Aoyama; A Inazu; H Mabuchi Journal: J Intern Med Date: 2002-08 Impact factor: 8.989
Authors: Howard N Hodis; Wendy J Mack; Stanley P Azen; Roger A Lobo; Donna Shoupe; Peter R Mahrer; David P Faxon; Linda Cashin-Hemphill; Miguel E Sanmarco; William J French; Thomas L Shook; Thomas D Gaarder; Anilkumar O Mehra; Ramin Rabbani; Alex Sevanian; Asit B Shil; Mina Torres; K Heiner Vogelbach; Robert H Selzer Journal: N Engl J Med Date: 2003-08-07 Impact factor: 91.245
Authors: Alice Dillard; Nirupa R Matthan; Nicole L Spartano; Ann E Butkowski; Alice H Lichtenstein Journal: Lipids Date: 2013-10-06 Impact factor: 1.880