Literature DB >> 17803899

A fight for neurotransmission: SCRAPPER trashes RIM.

Frederick Dobie1, Ann Marie Craig.   

Abstract

The presynaptic scaffold molecule RIM1alpha is important for regulating neurotransmitter release. In this issue, Yao et al. (2007) show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1alpha for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check.

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Year:  2007        PMID： 17803899      PMCID： PMC2821330          DOI： 10.1016/j.cell.2007.08.020

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  11 in total

1.  RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.

Authors:  Susanne Schoch; Pablo E Castillo; Tobias Jo; Konark Mukherjee; Martin Geppert; Yun Wang; Frank Schmitz; Robert C Malenka; Thomas C Südhof
Journal:  Nature       Date:  2002-01-17       Impact factor: 49.962

2.  The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy.

Authors:  Sean D Speese; Nick Trotta; Chris K Rodesch; Bharathi Aravamudan; Kendal Broadie
Journal:  Curr Biol       Date:  2003-05-27       Impact factor: 10.834

3.  Independent regulation of synaptic size and activity by the anaphase-promoting complex.

Authors:  Peter van Roessel; David A Elliott; Iain M Robinson; Andreas Prokop; Andrea H Brand
Journal:  Cell       Date:  2004-11-24       Impact factor: 41.582

Review 4.  Ubiquitin and protein turnover in synapse function.

Authors:  Jason J Yi; Michael D Ehlers
Journal:  Neuron       Date:  2005-09-01       Impact factor: 17.173

5.  Activity-dependent dynamics and sequestration of proteasomes in dendritic spines.

Authors:  Baris Bingol; Erin M Schuman
Journal:  Nature       Date:  2006-06-29       Impact factor: 49.962

6.  Proteasome inhibition triggers activity-dependent increase in the size of the recycling vesicle pool in cultured hippocampal neurons.

Authors:  Kristen Willeumier; Stefan M Pulst; Felix E Schweizer
Journal:  J Neurosci       Date:  2006-11-01       Impact factor: 6.167

7.  Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination.

Authors:  Mei Ding; Dan Chao; George Wang; Kang Shen
Journal:  Science       Date:  2007-07-12       Impact factor: 47.728

Review 8.  RIM function in short- and long-term synaptic plasticity.

Authors:  P S Kaeser; T C Südhof
Journal:  Biochem Soc Trans       Date:  2005-12       Impact factor: 5.407

9.  Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans.

Authors:  Michelle Burbea; Lars Dreier; Jeremy S Dittman; Maria E Grunwald; Joshua M Kaplan
Journal:  Neuron       Date:  2002-07-03       Impact factor: 17.173

10.  SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.

Authors:  Ikuko Yao; Hiroshi Takagi; Hiroshi Ageta; Tomoaki Kahyo; Showbu Sato; Ken Hatanaka; Yoshiyuki Fukuda; Tomoki Chiba; Nobuhiro Morone; Shigeki Yuasa; Kaoru Inokuchi; Toshihisa Ohtsuka; Grant R Macgregor; Keiji Tanaka; Mitsutoshi Setou
Journal:  Cell       Date:  2007-09-07       Impact factor: 41.582
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  4 in total

1.  A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.

Authors:  Senthilkumar Deivasigamani; Anagha Basargekar; Kumari Shweta; Pooja Sonavane; Girish S Ratnaparkhi; Anuradha Ratnaparkhi
Journal:  Genetics       Date:  2015-08-19       Impact factor: 4.562

Review 2.  Small molecule therapeutics targeting F-box proteins in cancer.

Authors:  Yuan Liu; Rama K Mallampalli
Journal:  Semin Cancer Biol       Date:  2015-09-30       Impact factor: 15.707

3.  SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex.

Authors:  Kohei Koga; Ikuko Yao; Mitsutoshi Setou; Min Zhuo
Journal:  J Neurosci       Date:  2017-03-14       Impact factor: 6.167

4.  SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses.

Authors:  Hiroshi Takagi; Mitsutoshi Setou; Seiji Ito; Ikuko Yao
Journal:  Neural Plast       Date:  2012-12-20       Impact factor: 3.599
  4 in total

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