Literature DB >> 178029

Hypothalamic and pituitary effects of prostaglandins on ACTH secretion.

G A Hedge.   

Abstract

Various prostaglandins (PGs) were tested for their effects on ACTH secretion upon injection into the anterior pituitary, basomedial hypothalamus, basolateral hypothalamus, or a tail vein in anesthetized female rats. In some experiments, the PGs were injected in combination with a CRF preparation. The greatest effect seen was the stimulation of ACTH (and presumably CRF) secretion exerted at the basomedial hypothalamus. At the anterior pituitary, the PGs alone were without effect, but they did decrease the magnitude of the response to subsequent CRF.

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Year:  1976        PMID： 178029     DOI： 10.1016/0090-6980(76)90152-0

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  4 in total

1.  Ultrastructure and morphometry of ACTH-producing cell in the rat anterior pituitary gland stimulated by lysin-vasopressin and prostaglandin E1.

Authors:  J Caselitz; W Saeger
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1978-05-05

Review 2.  Immunomodulatory peptides and the central nervous system.

Authors:  N R Hall; J P McGillis; B L Spangelo; D L Healy; A L Goldstein
Journal:  Springer Semin Immunopathol       Date:  1985

3.  Effect of prostaglandin E2 on ACTH and beta-endorphin release from rat adenohypophysis in vitro after secretagogues which can mimic various first or second messengers.

Authors:  W Knepel; D Götz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-06       Impact factor: 3.000

4.  A direct inhibitory action of prostaglandins upon ACTH secretion at the late stages of the secretory pathway of AtT-20 cells.

Authors:  Mary L Wilson; Simon B Guild
Journal:  Br J Pharmacol       Date:  2002-04       Impact factor: 8.739
  4 in total

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