Literature DB >> 17799846

Antibody to Rat Kidney: In vivo Effects of Univalent and Divalent Fragments.

J H Baxter, P A Small.   

Abstract

Whereas intact antibody to rat kidney (7S) produced immediate and sustained proteinuria in rats, univalent fragments (papain digests) of the antibody did not, and divalent fragments (pepsin digests) produced only transitory proteinuria. The antibody fragments differed from the intact antibody in fixing little, if any, complement in vivo which may explain why they did not cause serious renal damage.

Entities:  

Year:  1963        PMID： 17799846     DOI： 10.1126/science.140.3574.1406

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Antibody-induced glomerular injury.

Authors:  H G Rennke
Journal:  Klin Wochenschr       Date:  1985-09-16

2.  [Passive nephrotoxic nephritis].

Authors:  A Vogt; L Reich; K Nakanoin
Journal:  Virchows Arch Pathol Anat Physiol Klin Med       Date:  1966-10-10

3.  [Species-caused differences in the course of experimental rat nephritis following injection of rabbit-and duck antirat kidney serum].

Authors:  K Nakanoin; A Vogt
Journal:  Virchows Arch Pathol Anat Physiol Klin Med       Date:  1965-12-21

4.  Guinea-pig nephrotoxic nephritis. I. The role of complement and polymorphonuclear leucocytes and the effect of antibody subclass and fragments in the heterologous phase.

Authors:  I J Simpson; N Amos; D J Evans; N M Thomson; D K Peters
Journal:  Clin Exp Immunol       Date:  1975-03       Impact factor: 4.330

Review 5.  The role of complement in experimental disease models.

Authors:  C G Cochrane
Journal:  Springer Semin Immunopathol       Date:  1984

6.  PEPSIN DIGESTION OF RABBIT AND SHEEP ANTIBODIES. THE EFFECT ON COMPLEMENT FIXATION.

Authors:  P H SCHUR; E L BECKER
Journal:  J Exp Med       Date:  1963-12-01       Impact factor: 14.307

7.  EXPERIMENTAL GLOMERULONEPHRITIS. IV. PARTICIPATION OF COMPLEMENT IN NEPHROTOXIC NEPHRITIS.

Authors:  E UNANUE; F J DIXON
Journal:  J Exp Med       Date:  1964-01-01       Impact factor: 14.307
  7 in total

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