Literature DB >> 17796164

Inactivation of Penicillins G and K by Liver and Kidney.

J Tepperman, N Rakieten, G Valley, E W Lyon.   

Abstract

The inactivation of penicillin K is more rapid in the renal-ligated rabbit than in the renal-ligated, eviscerate preparation. Inactivation of penicillin K occurs in the presence of surviving liver and kidney slices. Small amounts of penicillin G were inactivated by liver slices; larger amounts disappeared in the presence of kidney slices. The inactivation of penicillin K in the presence of rabbit liver and kidney slices is demonstrable anaerobically as well as aerobically.

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Keywords:  PENICILLIN/G; PENICILLIN/K; PENICILLIN/metabolism

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Year:  1947        PMID: 17796164     DOI: 10.1126/science.105.2714.18

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  1 in total

1.  THE RENAL CLEARANCE OF PENICILLINS F, G, K, AND X IN RABBITS AND MAN.

Authors:  H Eagle; E Newman; A D Musselman; M Robinson; M Birmingham
Journal:  J Clin Invest       Date:  1947-09       Impact factor: 14.808

  1 in total

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