| Literature DB >> 17786636 |
Mei-Hui Hsu1, Uzen Savas, Keith J Griffin, Eric F Johnson.
Abstract
The microsomal cytochrome P450 (CYP) family 4 monooxygenases are the major fatty acid omega-hydroxylases. These enzymes remove excess free fatty acids to prevent lipotoxicity, catabolize leukotrienes and prostanoids, and also produce bioactive metabolites from arachidonic acid omega-hydroxylation. In addition to endogenous substrates, recent evidence indicates that CYP4 monooxygenases can also metabolize xenobiotics, including therapeutic drugs. This review focuses on human CYP4 enzymes and updates current knowledge concerning catalytic activity profiles, genetic variation and regulation of expression. Comparative differences between the human and rodent CYP4 enzymes regarding catalytic function and conditional expression are also discussed.Entities:
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Year: 2007 PMID： 17786636 DOI： 10.1080/03602530701468573
Source DB: PubMed Journal: Drug Metab Rev ISSN： 0360-2532 Impact factor: 4.518