Literature DB >> 17786587

Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics.

George N Phillips1, Brian G Fox, John L Markley, Brian F Volkman, Euiyoung Bae, Eduard Bitto, Craig A Bingman, Ronnie O Frederick, Jason G McCoy, Betsy L Lytle, Brad S Pierce, Jikui Song, Simon N Twigger.   

Abstract

The Center for Eukaryotic Structural Genomics (CESG) produces and solves the structures of proteins from eukaryotes. We have developed and operate a pipeline to both solve structures and to test new methodologies. Both NMR and X-ray crystallography methods are used for structure solution. CESG chooses targets based on sequence dissimilarity to known structures, medical relevance, and nominations from members of the scientific community. Many times proteins qualify in more than one of these categories. Here we review some of the structures that have connections to human health and disease.

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Year:  2007        PMID： 17786587     DOI： 10.1007/s10969-007-9023-6

Source DB:  PubMed          Journal:  J Struct Funct Genomics        ISSN： 1345-711X


  111 in total

1.  Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients.

Authors:  J Jiang; L Yu; X Huang; X Chen; D Li; Y Zhang; L Tang; S Zhao
Journal:  Gene       Date:  2001-12-27       Impact factor: 3.688

Review 2.  Dynein and dynein-related genes.

Authors:  I Milisav
Journal:  Cell Motil Cytoskeleton       Date:  1998

3.  Human pancreatic RNase1-human epidermal growth factor fusion: an entirely human 'immunotoxin analog' with cytotoxic properties against squamous cell carcinomas.

Authors:  K Psarras; M Ueda; T Yamamura; S Ozawa; M Kitajima; S Aiso; S Komatsu; M Seno
Journal:  Protein Eng       Date:  1998-12

4.  A dimeric mutant of human pancreatic ribonuclease with selective cytotoxicity toward malignant cells.

Authors:  R Piccoli; S Di Gaetano; C De Lorenzo; M Grauso; C Monaco; D Spalletti-Cernia; P Laccetti; J Cinátl; J Matousek; G D'Alessio
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

5.  Characteristics of the cysteinesulfinate-forming enzyme system in rat liver.

Authors:  L Ewetz; B Sörbo
Journal:  Biochim Biophys Acta       Date:  1966-11-15

6.  Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A.

Authors:  B Kobe; J Deisenhofer
Journal:  J Mol Biol       Date:  1996-12-20       Impact factor: 5.469

7.  Secretagogin is a new neuroendocrine marker in the human prostate.

Authors:  Katja Adolf; Ludwig Wagner; Anders Bergh; Pär Stattin; Peter Ottosen; Michael Borre; Karin Birkenkamp-Demtröder; Torben Falck Orntoft; Niels Tørring
Journal:  Prostate       Date:  2007-04-01       Impact factor: 4.104

8.  Production in two-liter beverage bottles of proteins for NMR structure determination labeled with either 15N- or 13C-15N.

Authors:  Qin Zhao; Ronnie Frederick; Kory Seder; Sandy Thao; Hassan Sreenath; Francis Peterson; Brian F Volkman; John L Markley; Brian G Fox
Journal:  J Struct Funct Genomics       Date:  2004

9.  The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a.

Authors:  Nicholas R Silvaggi; Chunchun Zhang; Zhibing Lu; Jianying Dai; Debra Dunaway-Mariano; Karen N Allen
Journal:  J Biol Chem       Date:  2006-03-15       Impact factor: 5.157

Review 10.  Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine.

Authors:  Martha H Stipanuk
Journal:  Annu Rev Nutr       Date:  2004       Impact factor: 11.848
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  7 in total

1.  Retrospective analyses of the bottleneck in purification of eukaryotic proteins from Escherichia coli as affected by molecular weight, cysteine content and isoelectric point.

Authors:  Won Bae Jeon
Journal:  BMB Rep       Date:  2010-05       Impact factor: 4.778

2.  The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein.

Authors:  Paulette L Hayes; Betsy L Lytle; Brian F Volkman; Francis C Peterson
Journal:  Protein Sci       Date:  2008-03       Impact factor: 6.725

Review 3.  Cell-free translation of integral membrane proteins into unilamelar liposomes.

Authors:  Michael A Goren; Akira Nozawa; Shin-ichi Makino; Russell L Wrobel; Brian G Fox
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

4.  Rapid, robotic, small-scale protein production for NMR screening and structure determination.

Authors:  Davin R Jensen; Christopher Woytovich; Margie Li; Petar Duvnjak; Michael S Cassidy; Ronnie O Frederick; Lai F Bergeman; Francis C Peterson; Brian F Volkman
Journal:  Protein Sci       Date:  2010-03       Impact factor: 6.725

5.  The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata.

Authors:  Diane O Inglis; Martha B Arnaud; Jonathan Binkley; Prachi Shah; Marek S Skrzypek; Farrell Wymore; Gail Binkley; Stuart R Miyasato; Matt Simison; Gavin Sherlock
Journal:  Nucleic Acids Res       Date:  2011-11-07       Impact factor: 16.971

6.  The Protein Model Portal--a comprehensive resource for protein structure and model information.

Authors:  Juergen Haas; Steven Roth; Konstantin Arnold; Florian Kiefer; Tobias Schmidt; Lorenza Bordoli; Torsten Schwede
Journal:  Database (Oxford)       Date:  2013-04-26       Impact factor: 3.451

7.  Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.

Authors:  Joaquim Rui Rodrigues; Ascensión Fernández; José Canales; Alicia Cabezas; João Meireles Ribeiro; María Jesús Costas; José Carlos Cameselle
Journal:  PLoS One       Date:  2012-07-27       Impact factor: 3.240
  7 in total

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