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Literature DB >> 17786230

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets.

Abstract

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

Entities: Disease

Mesh：

Substances：
MicroRNAs

Year: 2007 PMID： 17786230 PMCID： PMC1952642 DOI： 10.1172/JCI33099

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

63 in total

1. The Microprocessor complex mediates the genesis of microRNAs.

Authors: Richard I Gregory; Kai-Ping Yan; Govindasamy Amuthan; Thimmaiah Chendrimada; Behzad Doratotaj; Neil Cooch; Ramin Shiekhattar
Journal: Nature Date: 2004-11-07 Impact factor: 49.962

2. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.

Authors: Benjamin P Lewis; Christopher B Burge; David P Bartel
Journal: Cell Date: 2005-01-14 Impact factor: 41.582

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Authors: D Srivastava; T Thomas; Q Lin; M L Kirby; D Brown; E N Olson
Journal: Nat Genet Date: 1997-06 Impact factor: 38.330

Review 4. Incidence of congenital heart disease: II. Prenatal incidence.

Authors: J I Hoffman
Journal: Pediatr Cardiol Date: 1995 Jul-Aug Impact factor: 1.655

5. Myosin heavy chain gene expression in human heart failure.

Authors: K Nakao; W Minobe; R Roden; M R Bristow; L A Leinwand
Journal: J Clin Invest Date: 1997-11-01 Impact factor: 14.808

6. Impact of beta-myosin heavy chain expression on cardiac function during stress.

Authors: Maike Krenz; Jeffrey Robbins
Journal: J Am Coll Cardiol Date: 2004-12-21 Impact factor: 24.094

7. Processing of primary microRNAs by the Microprocessor complex.

Authors: Ahmet M Denli; Bastiaan B J Tops; Ronald H A Plasterk; René F Ketting; Gregory J Hannon
Journal: Nature Date: 2004-11-07 Impact factor: 49.962

8. Influence of thyroid status on the differentiation of slow and fast muscle phenotypes.

Authors: A Vadászová; G Zacharová; K Machácová; I Jirmanová; T Soukup
Journal: Physiol Res Date: 2004 Impact factor: 1.881

9. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.

Authors: R C Lee; R L Feinbaum; V Ambros
Journal: Cell Date: 1993-12-03 Impact factor: 41.582

10. MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts.

Authors: Jiening Xiao; Xiaobin Luo; Huixian Lin; Ying Zhang; Yanjie Lu; Ning Wang; Yiqiang Zhang; Baofeng Yang; Zhiguo Wang
Journal: J Biol Chem Date: 2007-03-07 Impact factor: 5.157

229 in total

1. Circulating and renal vein levels of microRNAs in patients with renal artery stenosis.

Authors: Moo Yong Park; Sandra M Herrmann; Ahmed Saad; Robert Jay Widmer; Hui Tang; Xiang-Yang Zhu; Amir Lerman; Stephen C Textor; Lilach O Lerman
Journal: Nephrol Dial Transplant Date: 2014-10-31 Impact factor: 5.992

Review 2. Horizontal transfer of microRNAs: molecular mechanisms and clinical applications.

Authors: Xi Chen; Hongwei Liang; Junfeng Zhang; Ke Zen; Chen-Yu Zhang
Journal: Protein Cell Date: 2012-02-09 Impact factor: 14.870

3. MicroRNAs: Novel Regulators of the Heart.

Authors: Junjie Xiao; Yi-Han Chen
Journal: J Thorac Dis Date: 2010-03 Impact factor: 2.895

Review 4. Vascular smooth muscle phenotypic diversity and function.

Authors: Steven A Fisher
Journal: Physiol Genomics Date: 2010-08-24 Impact factor: 3.107

5. MicroRNAs as new players in the genomic galaxy and disease puzzles.

Authors: Elisa Barbarotto; Paola Secchiero; Abhijit Dasgupta; Paolo Fortina; George A Calin; Terry Hyslop
Journal: Clin Transl Sci Date: 2008-05 Impact factor: 4.689

6. Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2.

Authors: Ngan K Vo; Ryan P Dalton; Ning Liu; Eric N Olson; Richard H Goodman
Journal: Proc Natl Acad Sci U S A Date: 2010-10-25 Impact factor: 11.205

7. miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in the type 1 diabetic heart.

Authors: Walter A Baseler; Dharendra Thapa; Rajaganapathi Jagannathan; Erinne R Dabkowski; Tara L Croston; John M Hollander
Journal: Am J Physiol Cell Physiol Date: 2012-10-03 Impact factor: 4.249

8. Searching for miR-acles in cardiac fibrosis.

Authors: Eva van Rooij; Eric N Olson
Journal: Circ Res Date: 2009-01-30 Impact factor: 17.367

9. Peripheral myelin protein 22 is regulated post-transcriptionally by miRNA-29a.

Authors: Jonathan D Verrier; Pierre Lau; Lynn Hudson; Alexander K Murashov; Rolf Renne; Lucia Notterpek
Journal: Glia Date: 2009-09 Impact factor: 7.452

10. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice.

Authors: Andrew H Williams; Gregorio Valdez; Viviana Moresi; Xiaoxia Qi; John McAnally; Jeffrey L Elliott; Rhonda Bassel-Duby; Joshua R Sanes; Eric N Olson
Journal: Science Date: 2009-12-11 Impact factor: 47.728