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Literature DB >> 1778609

The C5 isozyme of serum cholinesterase and adult weight.

E A Chautard-Freire-Maia¹, S L Primo-Parmo, G Picheth, M A Lourenço, M M Vieira.

Abstract

The relationship between the CHE2 locus of serum cholinesterase (BChE) and adult human weight was studied in a sample of 225 CHE2 C5+ individuals and 225 CHE2 C5- controls matched for sex, height, age and race. With respect to the intensity of the C5 band staining (scored 1-6), 113 individuals had faint C5 bands (scores 1-3) and 112 intense C5 bands (scores 4-6). The individuals with intense CHE2 C5+ phenotype showed a significantly lower mean adult weight (64.66 +/- 0.73 kg) when compared to their controls (70.59 +/- 0.97 kg) and a significant reduction in weight variance (59.81 and 105.18, respectively). Individuals with faint C5 bands, although showing a negative correlation between weight and C5 band intensity, did not differ from their controls in mean weight.

Entities: Gene Species

Mesh：

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Year: 1991 PMID： 1778609 DOI： 10.1159/000154021

Source DB: PubMed Journal: Hum Hered ISSN： 0001-5652 Impact factor: 0.444

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Cited

10 in total

1. GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.

Authors: Beben Benyamin; Rita P Middelberg; Penelope A Lind; Anne M Valle; Scott Gordon; Dale R Nyholt; Sarah E Medland; Anjali K Henders; Andrew C Heath; Pamela A F Madden; Peter M Visscher; Daniel T O'Connor; Grant W Montgomery; Nicholas G Martin; John B Whitfield
Journal: Hum Mol Genet Date: 2011-08-23 Impact factor: 6.150

2. Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet.

Authors: Vicky Ping Chen; Yang Gao; Liyi Geng; Michael B Stout; Michael D Jensen; Stephen Brimijoin
Journal: Endocrinology Date: 2016-06-14 Impact factor: 4.736

3. Characterization of 12 silent alleles of the human butyrylcholinesterase (BCHE) gene.

Authors: S L Primo-Parmo; C F Bartels; B Wiersema; A F van der Spek; J W Innis; B N La Du
Journal: Am J Hum Genet Date: 1996-01 Impact factor: 11.025

Review 4. Ghrelin and liver disease.

Authors: Mar Quiñones; Johan Fernø; Omar Al-Massadi
Journal: Rev Endocr Metab Disord Date: 2020-03 Impact factor: 6.514

The C5 isozyme of serum cholinesterase and adult weight.

1. GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.

2. Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet.

3. Characterization of 12 silent alleles of the human butyrylcholinesterase (BCHE) gene.

Review 4. Ghrelin and liver disease.

5. Effects of physical exercise on butyrylcholinesterase in obese adolescents.

6. Molecular forms of butyrylcholinesterase and obesity.

7. Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes.

8. Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women.

9. The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment.

10. Influence of Serum Cholinesterase Levels on Patients Suspected of Having Stable Coronary Artery Disease.