Literature DB >> 17785173

A silver bullet for the treatment of depression?

Ronald S Duman1.   

Abstract

The search for a rapid-acting antidepressant has been a subject of intense research interest for several decades. The article by Lucas and colleagues in this issue of Neuron provides compelling evidence from preclinical animal models that drugs acting at the serotonin 5-HT(4) receptor could finally achieve this goal. However, caution is warranted, as results from animal studies are not always predictive of therapeutic actions in humans.

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Year:  2007        PMID： 17785173     DOI： 10.1016/j.neuron.2007.08.011

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  9 in total

1.  Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.

Authors:  Peng Zhong; Xiaojie Liu; Zhen Zhang; Ying Hu; Sarah J Liu; Martha Lezama-Ruiz; Milan Joksimovic; Qing-song Liu
Journal:  J Neurosci       Date:  2014-04-30       Impact factor: 6.167

2.  Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress.

Authors:  Wei Wang; Dalong Sun; Bin Pan; Christopher J Roberts; Xinglai Sun; Cecilia J Hillard; Qing-song Liu
Journal:  Neuropsychopharmacology       Date:  2010-07-21       Impact factor: 7.853

3.  Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat.

Authors:  Guillaume Lucas; Jenny Du; Thomas Romeas; Ouissame Mnie-Filali; Nasser Haddjeri; Graciela Piñeyro; Guy Debonnel
Journal:  PLoS One       Date:  2010-02-16       Impact factor: 3.240

4.  Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling.

Authors:  Peng Zhong; Wei Wang; Bin Pan; Xiaojie Liu; Zhen Zhang; Jonathan Z Long; Han-ting Zhang; Benjamin F Cravatt; Qing-song Liu
Journal:  Neuropsychopharmacology       Date:  2014-01-30       Impact factor: 7.853

Review 5.  Serotonin receptors in hippocampus.

Authors:  Laura Cristina Berumen; Angelina Rodríguez; Ricardo Miledi; Guadalupe García-Alcocer
Journal:  ScientificWorldJournal       Date:  2012-05-02

6.  HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress.

Authors:  Peng Zhong; Casey R Vickstrom; Xiaojie Liu; Ying Hu; Laikang Yu; Han-Gang Yu; Qing-Song Liu
Journal:  Elife       Date:  2018-01-02       Impact factor: 8.140

7.  The Effect of the 5-HT4 Agonist, Prucalopride, on a Functional Magnetic Resonance Imaging Faces Task in the Healthy Human Brain.

Authors:  Angharad N de Cates; Marieke A G Martens; Lucy C Wright; Cassandra D Gould van Praag; Liliana P Capitão; Daisy Gibson; Philip J Cowen; Catherine J Harmer; Susannah E Murphy
Journal:  Front Psychiatry       Date:  2022-04-12       Impact factor: 5.435

8.  CB2 Agonist GW842166x Protected against 6-OHDA-Induced Anxiogenic- and Depressive-Related Behaviors in Mice.

Authors:  Xiaojie Liu; Hao Yu; Bixuan Chen; Vladislav Friedman; Lianwei Mu; Thomas J Kelly; Gonzalo Ruiz-Pérez; Li Zhao; Xiaowen Bai; Cecilia J Hillard; Qing-Song Liu
Journal:  Biomedicines       Date:  2022-07-22

9.  Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response.

Authors:  K Ganea; A Menke; M V Schmidt; S Lucae; G Rammes; C Liebl; D Harbich; V Sterlemann; C Storch; M Uhr; F Holsboer; E B Binder; I Sillaber; M B Müller
Journal:  Transl Psychiatry       Date:  2012-10-23       Impact factor: 6.222
  9 in total

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